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1001353-78-1

1001353-78-1

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1001353-78-1 Usage

General Description

L-Proline, 1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-2-Methyl- is a chemical compound with a complex structure. It contains a proline amino acid linked to a pyrrolo[2,1-f][1,2,4]triazin-2-yl group via a 4-amino pyrazole linker. The compound also features a cyclopropyl group and a methyl group, which add to its overall structure and properties. This chemical is of interest to researchers and pharmaceutical companies for its potential biological activities and therapeutic applications, but further studies are needed to fully understand its potential.

Check Digit Verification of cas no

The CAS Registry Mumber 1001353-78-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,0,1,3,5 and 3 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1001353-78:
(9*1)+(8*0)+(7*0)+(6*1)+(5*3)+(4*5)+(3*3)+(2*7)+(1*8)=81
81 % 10 = 1
So 1001353-78-1 is a valid CAS Registry Number.

1001353-78-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-1-(4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)-2-methylpyrrolidine-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names (S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrrolo[1,2-f][1,2,4]triazin-2-yl)-2-methylpyrrolidine-2-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1001353-78-1 SDS

1001353-78-1Relevant articles and documents

Discovery of a 2,4-disubstituted pyrrolo-[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development

Wittman, Mark D.,Carboni, Joan M.,Yang, Zheng,Lee, Francis Y.,Antman, Melissa,Attar, Ricardo,Balimane, Praveen,Chang, Chiehying,Chen, Cliff,Discenza, Lorell,Frennesson, David,Gottardis, Marco M.,Greer, Ann,Hurlburt, Warren,Johnson, Walter,Langley, David R.,Li, Aixin,Li, Jianqing,Liu, Peiying,Mastalerz, Harold,Mathur, Arvind,Menard, Krista,Patel, Karishma,Sack, John,Sang, Xiaopeng,Saulnier, Mark,Smith, Daniel,Stefanski, Kevin,Trainor, George,Velaparthi, Upender,Zhang, Guifen,Zimmermann, Kurt,Vyas, Dolatrai M.

, p. 7360 - 7363 (2009)

This report describes the biological activity, characterization, and SAR leading to 9d (BMS-754807) a small molecule IGF-1R kinase inhibitor in clinical development. 2009 American Chemical Society.

PYRROLOTRIAZINE KINASE INHIBITORS

-

, (2011/04/19)

The invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's Disease.

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