1001413-74-6

Basic information

• Product Name: [(R)-1-(4-fluorophenyl)-2-hydroxyethyl]carbamic acid tert-butyl ester
• Synonyms: [(R)-1-(4-fluorophenyl)-2-hydroxyethyl]carbamic acid tert-butyl ester
• CAS NO: 1001413-74-6
• Molecular Weight: 255.289
• Mol File: 1001413-74-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [(R)-1-(4-fluorophenyl)-2-hydroxyethyl]carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [(R)-1-(4-fluorophenyl)-2-hydroxyethyl]carbamic acid tert-butyl ester(1001413-74-6)
• EPA Substance Registry System: [(R)-1-(4-fluorophenyl)-2-hydroxyethyl]carbamic acid tert-butyl ester(1001413-74-6)

Safety Data

• Hazardous Substances Data: 1001413-74-6(Hazardous Substances Data)

Upstream product

• 196707-32-1 (2R)-2-{[(tert-butoxy)carbonyl]amino}-2-(4-fluorophenyl)acetic acid 
• 1234372-12-3 (1S)-2-bromo-1-(4-fluorophenyl)ethan-1-ol 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 18511-62-1 (2S)-2-(4-fluorophenyl)oxirane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 174770-74-2 (R)-2-amino-2-(4-fluorophenyl)ethanol 

Downstream Products

• 1308378-44-0 3-[(R)-2-amino-2-(4-fluoro-phenyl)-ethyl]-1-(2-fluoro-6-trifluoromethyl-benzyl)-6-methyl-5-[4-(3-nitro-benzyl)-piperazin-1-yl]-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Synthesis of enantiopure 1,2-azido and 1,2-amino alcohols via regio- and stereoselective ring-opening of enantiopure epoxides by sodium azide in hot water

A practical and convenient method for the efficient and regio- and stereoselective ring-opening of enantiopure monosubstituted epoxides by sodium azide under hydrolytic conditions is reported. The ring-opening of enantiopure styryl and pyridyl (S)-epoxides by N3- in hot water takes place preferentially at the internal position with complete inversion of configuration to produce (R)-2-azido ethanols with up to 99% enantio- and regioselectivity, while the (S)-adamantyl oxirane provides mainly the (S)-1-adamantyl-2-azido ethanol in excellent yield. In general, 1,2-amino ethanols were obtained in high yield and excellent enantiopurity by the reduction of the chiral 1,2-azido ethanols with PPh3 in water/THF, and then converted into the Boc or acetamide derivatives.

PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES

Compounds of formula (I): and their use in the inhibition of Trk activity are described.