1001847-07-9Relevant articles and documents
Stereocontrolled and convergent entry to CF2-sialosides: Synthesis of CF2-linked ganglioside GM4
Hirai, Go,Watanabe, Toru,Yamaguchi, Kazunori,Miyagi, Taeko,Sodeoka, Mikiko
, p. 15420 - 15421 (2008/09/19)
Sialidase-resistant ganglioside analogues having biological activities similar to those of natural gangliosides are expected to be important probes for clarifying the biological functions of gangliosides. Focusing on difluoromethylene-linked (CF2-linked) α(2,3)sialylgalactose as a core structure of sialidase-resistant ganglioside mimics, we have developed novel, stereocontrolled, and efficient methodologies to synthesize CF2-sialosides based on Ireland-Claisen rearrangement. CF2-linked α(2,3)sialylgalactose and CF2-linked GM4 were synthesized. Copyright