1001856-75-2Relevant articles and documents
Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists
Coleman, Paul J.,Schreier, John D.,McGaughey, Georgia B.,Bogusky, Michael J.,Cox, Christopher D.,Hartman, George D.,Ball, Richard G.,Harrell, C. Meacham,Reiss, Duane R.,Prueksaritanont, Thomayant,Winrow, Christopher J.,Renger, John J.
, p. 2311 - 2315 (2010)
Orexins are neuropeptides that regulate wakefulness and arousal. Small molecule antagonists of orexin receptors may provide a novel therapy for the treatment of insomnia and other sleep disorders. In this Letter we describe the design and synthesis of con
