1001856-77-4Relevant articles and documents
Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists
Coleman, Paul J.,Schreier, John D.,McGaughey, Georgia B.,Bogusky, Michael J.,Cox, Christopher D.,Hartman, George D.,Ball, Richard G.,Harrell, C. Meacham,Reiss, Duane R.,Prueksaritanont, Thomayant,Winrow, Christopher J.,Renger, John J.
scheme or table, p. 2311 - 2315 (2010/09/08)
Orexins are neuropeptides that regulate wakefulness and arousal. Small molecule antagonists of orexin receptors may provide a novel therapy for the treatment of insomnia and other sleep disorders. In this Letter we describe the design and synthesis of con
