100190-36-1Relevant articles and documents
Optimisation of a lithium magnesiate for use in the non-cryogenic asymmetric deprotonation of prochiral ketones
Francos, Javier,Zaragoza-Calero, Silvia,O'Hara, Charles T.
, p. 1408 - 1412 (2014/01/06)
A study has been conducted to determine whether lithium magnesiates are feasible candidates for the enantioselective deprotonation of 4-alkylcyclohexanones. The commercially available chiral amine (+)-bis[(R)-1-phenylethyl]amine (2-H) was utilised to indu
New potentially dhelating chiral magnesium amide bases for use in enantioselective deprotonation reactions
Kerr, William J.,Middleditch, Michael,Watson, Allan J. B.
supporting information; experimental part, p. 177 - 180 (2011/03/22)
A series of chiral secondary amines, incorporating a five- or six-membered heterocycle, were synthesised and used to prepare novel chiral magnesium bisamide reagents. These amide bases were subsequently applied within asymmetric deprotonation reactions to
Chiral and achiral lithium amides having a fluorous ponytail: Preparation and evaluation as a recycling reagent for lithium enolate generation
Matsubara, Hiroshi,Maeda, Louis,Sugiyama, Hiroyuki,Ryu, Ilhyong
, p. 2901 - 2912 (2008/03/13)
Diisopropylamine derivatives bearing a perfluoroalkyl chain were prepared and converted to the corresponding lithium amides by treatment with n-butyllithium. The fluorous lithium amides reacted with ketones to efficiently produce lithium enolates. Asymmetric deprotonation of prochiral ketones was also studied using lithium amides derived from chiral fluorous amines, which gave optical yields comparable with the parent nonfluorous chiral lithium amides. These reusable fluorous amines can be easily recovered by liquid-liquid extraction or chromatographic separation. Georg Thieme Verlag Stuttgart.
