1001909-95-0

Basic information

• Product Name: 2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanone
• Synonyms: 2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanone
• CAS NO: 1001909-95-0
• Molecular Weight: 326.179
• Mol File: 1001909-95-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanone(1001909-95-0)
• EPA Substance Registry System: 2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanone(1001909-95-0)

Safety Data

• Hazardous Substances Data: 1001909-95-0(Hazardous Substances Data)

Upstream product

• 100868-46-0 3,5-dichloro-4-picoline 
• 2150-38-1 methyl 3,4-dimethoxybenzoate 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 

Downstream Products

• 1113061-23-6 (R,S)-2-(3,5-dichloropyridin-4-yl)-1-(3,4-dimethoxyphenyl)ethanol 

Relevant articles and documents

Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4- pyridyl)acetyl]-2,3-dimethoxyphenoxy}- N -propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis

Development of orally available phosphodiesterase 4 (PDE4) inhibitors as anti-inflammatory drugs has been going on for decades. However, only roflumilast has received FDA approval. One key challenge has been the low therapeutic window observed in the clin

Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors

The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridynyl alkylene alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.