10023-07-1

Basic information

• Product Name: [(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid
• Synonyms: [1R-(1a,3b,4ab,10ab)]-3,4,5,10-Tetrahydro-9-hydroxy-5,10-dioxo-1-propyl-4a,10a-epoxy-1H-naphtho[2,3-c]pyran-3-acetic Acid; 10023-07-1
• CAS NO: 10023-07-1
• Molecular Formula: C₁₈H₁₈O₇
• Molecular Weight: 346.3313
• Mol File: 10023-07-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 655.774°C at 760 mmHg
• Flash Point: 243.284°C
• Density: 1.51g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: [(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid(10023-07-1)
• EPA Substance Registry System: [(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid(10023-07-1)

Safety Data

• Hazardous Substances Data: 10023-07-1(Hazardous Substances Data)

Usage

Description

[(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid is a complex organic molecule characterized by its unique structure, which includes a hydroxy group, a propyl group, an epoxybenzo[g]isochromen-3(1H)-yl group, and a carboxylic acid functional group. This intricate arrangement of atoms and functional groups endows the compound with potential pharmaceutical and medicinal properties, making it a subject of interest for further research and exploration within the scientific community.

Uses

Used in Pharmaceutical Industry:
[(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid is used as a potential therapeutic agent for various medical conditions due to its complex structure, which may allow it to interact with biological systems in unique and beneficial ways.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, [(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid serves as a subject of study for understanding its properties, potential applications, and the ways in which it can be modified or utilized to develop new drugs or treatments for various diseases and conditions.
Used in Drug Design and Development:
[(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid's unique structural features make it a valuable candidate for drug design and development, as it may be used to create new molecules with specific therapeutic effects or to improve the efficacy and safety of existing drugs.
Used in Biochemical Studies:
[(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid can be employed in biochemical studies to investigate its interactions with various biological targets, such as enzymes, receptors, or other proteins, which may provide insights into its potential therapeutic applications and mechanisms of action.
Used in Drug Delivery Systems:
Similar to other complex organic molecules with potential medicinal properties, [(1R,3S,4aS,10aR)-9-hydroxy-5,10-dioxo-1-propyl-3,4,5,10-tetrahydro-4a,10a-epoxybenzo[g]isochromen-3(1H)-yl]acetic acid may be utilized in the development of novel drug delivery systems to improve its bioavailability, targeting, and overall therapeutic efficacy.

Upstream product

• 73804-49-6 (+/-)-deoxyfrenolicin 
• 10023-09-3 (+/-)-frenolicin methyl ester 
• 73794-56-6 (7S,7aS,9R,11S,11aS,11bR)-2,2-Dimethyl-11-propyl-7,8,9,11,11a,11b-hexahydro-7aH-1,3,10-trioxa-benzo[de]anthracene-7,9-diol 
• 73794-58-8 ((7aS,9R,11S,11aS,11bR)-2,2-Dimethyl-7-oxo-11-propyl-7,8,9,11,11a,11b-hexahydro-7aH-1,3,10-trioxa-benzo[de]anthracen-9-yl)-acetic acid methyl ester 
• 77363-69-0 (E)-4-[(3aR,4S,5S,6S)-6-Hydroxy-4-((S)-1-hydroxy-butyl)-2,2-dimethyl-3a,4,5,6-tetrahydro-naphtho[1,8-de][1,3]dioxin-5-yl]-but-2-enoic acid methyl ester 
• 73804-48-5 trans-methyl <9-hydroxy-1-propyl-5,10-dioxo-3,4,5,10-tetrahydro-1H-naphtho<2,3-c>pyran-3-yl>acetate 
• 73794-57-7 ((7R,7aR,9S,11R,11aR,11bS)-7-Hydroxy-2,2-dimethyl-11-propyl-7,8,9,11,11a,11b-hexahydro-7aH-1,3,10-trioxa-benzo[de]anthracen-9-yl)-acetic acid methyl ester 
• 1450893-33-0 frenolicin F 

Downstream Products

• 10023-11-7 Deoxyfrenolicin 

Relevant articles and documents

Frenolicins C-G, Pyranonaphthoquinones from streptomyces sp. RM-4-15

Appalachian active coal fire sites were selected for the isolation of bacterial strains belonging to the class actinobacteria. A comparison of high-resolution electrospray ionization mass spectrometry (HRESIMS) and ultraviolet (UV) absorption profiles from isolate extracts to natural product databases suggested Streptomyces sp. RM-4-15 to produce unique metabolites. Four new pyranonaphthoquinones, frenolicins C-F (1-4), along with three known analogues, frenolicin (6), frenolicin B (7), and UCF76-A (8), were isolated from the fermentation of this strain. An additional new analogue, frenolicin G (5), along with two known compounds, deoxyfrenolicin (9) and UCF 13 (10), were isolated from the fermentation supplied with 18 mg/L of scandium chloride, the first example, to the best of our knowledge, wherein scandium chloride supplementation led to the confirmed production of new bacterial secondary metabolites. Structures 1-5 were elucidated on the basis of spectral analysis and chemical modification. While frenolicins are best known for their anticoccidial activity, the current study revealed compounds 6-9 to exhibit moderate cytotoxicity against the human lung carcinoma cell line (A549) and thereby extends the anticancer SAR for this privileged scaffold.