1002576-36-4

Basic information

• Product Name: (E)-8-nitro-2-styrylquinoline
• Synonyms: (E)-8-nitro-2-styrylquinoline
• CAS NO: 1002576-36-4
• Molecular Weight: 276.294
• Mol File: 1002576-36-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-8-nitro-2-styrylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-8-nitro-2-styrylquinoline(1002576-36-4)
• EPA Substance Registry System: (E)-8-nitro-2-styrylquinoline(1002576-36-4)

Safety Data

• Hazardous Substances Data: 1002576-36-4(Hazardous Substances Data)

Upstream product

• 881-07-2 8-nitroquinaldine 
• 100-46-9 benzylamine 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Lanthanum Pentafluorobenzoate-Catalyzed Aerobic Oxidative Olefination of Benzylamines with 2-Methylquinoline through Deamination and C-H Bond Functionalization

An efficient direct aerobic oxidative olefination of the methyl groups of 2-methylquinolines with benzylamines in the presence of a rare-earth-metal Lewis acid catalyst to give 2-styrylquinolines was successfully developed. Preliminary mechanistic studies revealed that the oxidative olefination reaction proceeds through a Lewis acid-catalyzed 2-methylquinoline-aldehyde condensation and an amine-aldehyde condensation.

Metal-free oxidative olefination of primary amines with benzylic C-H bonds through direct deamination and C-H bond activation

An oxidative olefination reaction between aliphatic primary amines and benzylic sp3 C-H bonds has been achieved using N-bromosuccinimide as catalyst and tert-butyl hydroperoxide as oxidant. The olefination proceeds under mild metal-free conditions through direct deamination and benzylic C-H bond activation, and provides easy access to biologically active 2-styrylquinolines with (E)-configuration. This journal is the Partner Organisations 2014.

Iron-catalyzed C(sp3)-H functionalization of methyl azaarenes: A green approach to azaarene-substituted α- Or β-hydroxy carboxylic derivatives and 2-alkenylazaarenes

Bioactive azaarene-substituted lactic acids, β-hydroxy esters, 3-hydroxy-2H-indol-2-ones, and 2-alkenylazaarenes were prepared in moderate-to-excellent yields via C(sp3)-H functionalization of methyl azaarenes with carbonyl compounds in the presence of iron(ii) acetate as an inexpensive, nontoxic, efficient catalyst. The application of this atom-, step-economic, and environmentally friendly method was demonstrated by a gram-scale synthesis of 3-[(E)-2-(7-chloroquinolin-2-yl)vinyl]benzaldehyde, a key intermediate of leukotriene receptor antagonist (Montelukast).