100276-22-0

Basic information

• Product Name: methyl 4-(2-chlorophenyl)-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3, 4-b]pyridine-3-carboxylate
• CAS NO: 100276-22-0
• Molecular Weight: 319.744
• Mol File: 100276-22-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 4-(2-chlorophenyl)-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3, 4-b]pyridine-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-chlorophenyl)-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3, 4-b]pyridine-3-carboxylate(100276-22-0)
• EPA Substance Registry System: methyl 4-(2-chlorophenyl)-1,4,5,7-tetrahydro-2-methyl-5-oxofuro[3, 4-b]pyridine-3-carboxylate(100276-22-0)

Safety Data

• Hazardous Substances Data: 100276-22-0(Hazardous Substances Data)

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 638-07-3 ethyl (2-chloroaceto)acetate 
• 89-98-5 2-chloro-benzaldehyde 
• 14205-39-1 methyl 3-aminocrotonate 
• 21731-17-9 methyl 3-aminocrotonate 
• 110464-44-3 2-Bromomethyl-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester 
• 43067-01-2 3,5-bis(methoxycarbonyl)-4-(2-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine 

Downstream Products

• 120289-25-0 4-(2-chlorophenyl)-5-keto-3-methoxycarbonyl-2-methyl-5,7-dihydrofuro-<3,4-b>pyridine 

Relevant articles and documents

Synthesis of unsymmetrical 1, 4-dihydropyridine derivatives in ionic liquid and inference on the formation mechanism of furopyridines

Aromatic aldehydes, methyl acetoacetate, ethyl acetoacetate, ammonium acetate, ethyl 4-chloroacetoacetate as materials, eight unsymmetrical 1, 4-dihydropyridine derivatives were synthesized in ionic liquid [Bmim]OH in short time with the 60%-90% yield, and the ionic liquid could be utilized for 5 times repeatedly with the no decrease of the yield, four of products [3(a-d)] (see in Table-1) were synthesized through Knoevenagel and Michael addition reaction, and another four Furopyridines [3(e-h)] (see in Table-2) through one-pot synthesis whose formation mechanism being different from that of [3(a-d)] was first inferred.

Biotransformation of amlodipine. Identification and synthesis of metabolites found in rat, dog and human urine / confirmation of structures by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry

Metabolism of the dihydropyridine calcium antagonist (R,S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5 methoxycarbonyl-6-methyl-1,4-dihydropyridine (amlodipine) has been studied in animals and man using 14C-labelled drug. The metabolite patterns are complex; 18 metabolites have been isolated from rat, dog and human urine. Based on chromatographic and mass-spectral evidence, structures have been proposed for the main metabolites and confirmed by synthesis of unambiguous reference compounds.