100377-32-0

Basic information

• Product Name: 4-Pyridinecarboxamide, N-methoxy-N-methyl-
• CAS NO: 100377-32-0
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Mol File: 100377-32-0.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 4-Pyridinecarboxamide, N-methoxy-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarboxamide, N-methoxy-N-methyl-(100377-32-0)
• EPA Substance Registry System: 4-Pyridinecarboxamide, N-methoxy-N-methyl-(100377-32-0)

Safety Data

• Hazardous Substances Data: 100377-32-0(Hazardous Substances Data)

Usage

Description

4-Pyridinecarboxamide, N-methoxy-N-methyl-, also known as nicotinamide N-methyl-4-pyridinium carboxamide, is a chemical compound derived from nicotinamide, a form of vitamin B3. It is recognized for its anti-inflammatory and anti-cancer properties and is widely utilized in the cosmetic and pharmaceutical industries.
Used in Cosmetic Industry:
4-Pyridinecarboxamide, N-methoxy-N-methylis used as an active ingredient in skincare products for its ability to enhance the skin barrier function and reduce the appearance of fine lines and wrinkles, thereby promoting overall skin health.
Used in Pharmaceutical Industry:
4-Pyridinecarboxamide, N-methoxy-N-methylis used as a potential therapeutic agent for treating and preventing certain types of cancer, capitalizing on its anti-inflammatory and anti-cancer properties.

Upstream product

• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 90322-87-5 1-isonicotinoyl-1H-imidazole 
• 55-22-1 pyridine-4-carboxylic acid 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 1117-97-1 N,0-dimethylhydroxylamine 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 243640-28-0 4-(2,3-dimethoxybenzoyl)pyridine 
• 14548-46-0 4-Benzoylpyridine 
• 1701-69-5 1-(4-pyridyl)-1-propanone 
• 1202375-46-9 4-(4-((6-fluoroquinolin-2-yl)methoxy)phenyl)-2,2-dimethyl-5-(pyridin-4-yl)furan-3(2H)-one 
• 1202368-23-7 2,2-dimethyl-5-(pyridin-4-yl)-4-(4-(quinolin-2-ylmethoxy)phenyl)furan-3(2H)-one 
• 1202375-45-8 4-(4-((3,5-dimethylpyridin-2-yl)methoxy)phenyl)-2,2-dimethyl-5-(pyridin-4-yl)furan-3(2H)-one 
• 1202375-44-7 2,2-dimethyl-4-(4-((5-methylpyridin-2-yl)methoxy)phenyl)-5-(pyridin-4-yl)furan-3(2H)-one 
• 1600563-64-1 C₂₆H₂₂ClN₅O 
• 1600564-19-9 C₂₇H₂₄ClN₅O 

Relevant articles and documents

Synthesis of the isonicotinoylnicotinamide scaffolds of the naturally occurring isoniazid-NAD(P) adducts

The first syntheses of the 1-hydroxy-1-(pyridin-4-yl)-1,2-dihydro-3H- pyrrolo[3,4-c]pyridin-3-one heterocycle and the 3-aminocarbonyl-4-isonicotinoyl- 1,4-dihydropyridine framework present in the isoniazid-NAD(P) adducts are described.

NH vs. CH hydrogen bond formation in metal-organic anion receptors containing pyrrolylpyridine ligands

Anion complexation studies on a series of platinum(II) tetrakis(pyrrolylpyridine) salts demonstrate the importance of CH-anion hydrogen bonds in coordinating anionic guests in solution and the solid-state. The Royal Society of Chemistry 2005.

Saturated Bioisosteres of ortho-Substituted Benzenes

Saturated bioisosteres of ortho-disubstituted benzenes (bicyclo[2.1.1]hexanes) were synthesized, characterized and validated. These cores were incorporated into the bioactive compounds Valsartan, Boskalid and Fluxapyroxad instead of the benzene ring. The

Design, synthesis and biological evaluation of anti-pancreatic cancer activity of plinabulin derivatives based on the co-crystal structure

Based on the co-crystal structures of tubulin with plinabulin and Compound 1 (a derivative of plinabulin), a total of 18 novel plinabulin derivatives were designed and synthesized. Their biological activities were evaluated against human pancreatic cancer BxPC-3 cell lines. Two novel Compounds 13d and 13e exhibited potent activities with IC50 at 1.56 and 1.72 nM, respectively. The tubulin polymerization assay indicated that these derivatives could inhibit microtubule polymerization. Furthermore, the interaction between tubulin and these compounds were elucidated by molecular docking. The binding modes of Compounds 13d and 13e were similar to the co-crystal structure of Compound 1. H-π interaction was observed between the aromatic hydrogen of thiophene moiety with Phe20, which could enhance their binding affinities.