100379-00-8 Usage
Description
2,6-Dimethylphenylboronic acid is an organic compound with the chemical formula C8H11BO2. It is a white crystalline powder that is commonly used in various chemical reactions and processes due to its unique properties.
Uses
Used in Suzuki Reaction:
2,6-Dimethylphenylboronic acid is used as a reagent for palladium-catalyzed Suzuki-Miyaura coupling reactions, which are widely employed in the synthesis of various organic compounds, including pharmaceuticals and natural products. It facilitates the formation of carbon-carbon bonds, making it a valuable tool in organic chemistry.
Used in Pd-Catalyzed Homocouplings:
2,6-Dimethylphenylboronic acid is also utilized in palladium-catalyzed homocouplings, a type of chemical reaction that involves the coupling of two identical molecules to form a larger molecule. This process is particularly useful in the synthesis of complex organic molecules.
Used in Rhodium(I)-Catalyzed 1,4-Addition Reactions:
2,6-Dimethylphenylboronic acid is employed in rhodium(I)-catalyzed 1,4-addition reactions, which are important in the synthesis of conjugated dienes and other unsaturated compounds. These reactions are crucial for the production of various chemicals and materials.
Used in the Preparation of Protein Kinase Inhibitors:
2,6-Dimethylphenylboronic acid is used in the preparation of protein kinase inhibitors, which are essential in the development of drugs targeting various diseases, including cancer and inflammatory conditions. Protein kinases are enzymes that play a significant role in cellular signaling pathways, and their inhibition can help regulate these pathways.
Used in the Preparation of G Protein-Coupled Receptor:
2,6-Dimethylphenylboronic acid is also used in the preparation of G protein-coupled receptors (GPCRs), which are a large family of proteins involved in various cellular processes. These receptors are important drug targets for treating a wide range of diseases, including neurological disorders, cardiovascular diseases, and metabolic conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 100379-00-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,3,7 and 9 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 100379-00:
(8*1)+(7*0)+(6*0)+(5*3)+(4*7)+(3*9)+(2*0)+(1*0)=78
78 % 10 = 8
So 100379-00-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H11BO2/c1-6-3-4-8(9(10)11)7(2)5-6/h3-5,10-11H,1-2H3
100379-00-8Relevant articles and documents
Concave reagents+. New 2′-substituted m-terphenyls
Abbass, Michael,Kuehl, Christine,Manthey, Christian,Mueller, Anja,Luening, Ulrich
, p. 1325 - 1344 (2004)
New 2′-substituted 2,2″,6,6″-tetramethyl-1,1′: 3′,1″-terphenyls have been synthesized. Solubility of concave acids 4b-6b could be enhanced by substitution in 4 and 4″ position, allowing the study of hydrogen-bonded heterodimers. Concave acids show larger
Photophysical properties of structural isomers of homoleptic Ir-complexes derived from xylenyl-substituted N-heterocyclic carbene ligands
Yun, Bo-Sun,Kim, Jin-Hyoung,Kim, So-Yoen,Son, Ho-Jin,Cho, Dae Won,Kang, Sang Ook
, p. 7155 - 7164 (2019)
The phosphorescence properties of fac-Ir(pmp)3, mer-Ir(pmp)3, fac-Ir(dmpmp)3 and mer-Ir(dmpmp)3 (where pmp = 3-methyl-1-phenyl-2,3-dihydro-1H-imidazo[4,5-b]pyridine and dmpmp = 1-(2′,6′-dimethylbiphenyl-2-yl)-3-
An efficient method for the hydrolysis of potassium organotrifluoroborates promoted by montmorillonite K10
Silva, Renato L.,Santos, Cosme S.,Santos, Jonh A. M.,Oliveira, Roberta A.,Menezes, Paulo H.,Freitas, Juliano C. R.
, p. 1777 - 1785 (2018/09/04)
An efficient and non-expensive method for conversion of diverse potassium organotrifluoroborates to their corresponding boronic acids promoted by montmorillonite K10 using water as the reaction solvent is described. Further interconversion of potassium organotrifluoroborates to their corresponding boronic esters, via boronic acid intermediates was also successfully accomplished. The products were obtained in good yields, being the rate of hydrolysis influenced by the type of substituent present in the boronic acid.
