100398-25-2Relevant articles and documents
Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain
Hall, Adrian,Brown, Susan H.,Budd, Christopher,Clayton, Nicholas M.,Giblin, Gerard M.P.,Goldsmith, Paul,Hayhow, Thomas G.,Hurst, David N.,Naylor, Alan,Anthony Rawlings,Scoccitti, Tiziana,Wilson, Alexander W.,Winchester, Wendy J.
, p. 497 - 501 (2011/03/18)
Herein we describe the medicinal chemistry programme to identify a potential back-up compound to the EP1 receptor antagonist GW848687X. This work started with the lipophilic 1,2-biaryl benzene derivative 4 which displayed molecular weight of 41
PYRIDYL COMPOUNDS
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Page/Page column 27, (2008/06/13)
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein R1, R2, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions compris
CYCLOHEXENE COMPOUNDS
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Page/Page column 25-26, (2010/02/11)
Formula (I) wherein A, B, Z, R1, R2a , R2b, R8, R9 and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.