100426-73-1

Basic information

• Product Name: (Z)-2-(2,6-Dichloro-5-fluoro-pyridine-3-carbonyl)-3-phenylamino-acrylic acid ethyl ester
• Synonyms: (Z)-2-(2,6-Dichloro-5-fluoro-pyridine-3-carbonyl)-3-phenylamino-acrylic acid ethyl ester
• CAS NO: 100426-73-1
• Molecular Weight: 383.206
• Mol File: 100426-73-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (Z)-2-(2,6-Dichloro-5-fluoro-pyridine-3-carbonyl)-3-phenylamino-acrylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(2,6-Dichloro-5-fluoro-pyridine-3-carbonyl)-3-phenylamino-acrylic acid ethyl ester(100426-73-1)
• EPA Substance Registry System: (Z)-2-(2,6-Dichloro-5-fluoro-pyridine-3-carbonyl)-3-phenylamino-acrylic acid ethyl ester(100426-73-1)

Safety Data

• Hazardous Substances Data: 100426-73-1(Hazardous Substances Data)

Upstream product

• 96568-04-6 ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate 
• 122-51-0 orthoformic acid triethyl ester 
• 62-53-3 aniline 
• 96568-02-4 2,6-dichloro-5-fluoro-3-nicotinoyl chloride 
• 82671-06-5 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid 
• 82671-03-2 ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate 

Downstream Products

• 104051-63-0 hydrochloride salt of 1-phenyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid 
• 104051-61-8 6-Fluoro-4-oxo-1-phenyl-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 100426-74-2 7-Chloro-6-fluoro-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 105572-98-3 7-(3-acetylamino-pyrrolidin-1-yl)-6-fluoro-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 1

In an attempt to search for clinically useful antitumor agents, we have discovered that a series of 1,7-disubstituted-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids possessed moderate cytotoxic activity. We investigated the structure-acti