100485-57-2

Basic information

• Product Name: Indan-1-one oxime
• Synonyms: Indan-1-one oxime
• CAS NO: 100485-57-2
• Molecular Weight: 147.177
• Mol File: 100485-57-2.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: Indan-1-one oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Indan-1-one oxime(100485-57-2)
• EPA Substance Registry System: Indan-1-one oxime(100485-57-2)

Safety Data

• Hazardous Substances Data: 100485-57-2(Hazardous Substances Data)

Upstream product

• 78386-35-3 ethyl-(2-bromo-indan-1-yl)-ether 
• 34698-41-4 2,3-dihydro-1H-inden-1-amine 
• 68253-35-0 (E)-indan-1-one oxime 
• 501-52-0 3-Phenylpropionic acid 
• 10368-44-2 trans-2-bromo-1-indanol 
• 19598-15-3 trans-1,2-bromoindane 
• 10485-09-3 2-bromoindene 
• 28873-89-4 2-Formylcinnamic acid 
• 776-79-4 2-(2-carboxyethyl)benzoic acid 
• 681856-01-9 indan-1-one-O-(phenylmethyl)oxime 
• 95-13-6 1-indene 
• 83-33-0 inden-1-one 

Downstream Products

• 860746-62-9 N-((1S,3aR,7aR)-octahydro-1H-inden-1-yl)acetamide 
• 10277-74-4 (S)-1-Aminoindane 

Relevant articles and documents

A novel synthesis of rasagiline via a chemoenzymatic dynamic kinetic resolution

A novel synthetic route for preparing rasagiline mesylate is presented using a dynamic kinetic resolution (DKR) as the key step, catalyzed by Candida antarctica lipase B (CALB) and a Pd nanocatalyst. The chiral intermediate (R)-2,3-dihydro-1-indanamine was obtained through the DKR of the racemic aminoindan rac-1 in high yield (>90%) and excellent enantioselectivity (>99% ee). The process could be conducted on a 73 g scale at 200 g/L. Rasagiline mesylate was synthesized in 25% overall yield and excellent enantioselectivity (99.9% ee) over 7 steps.

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Asymmetric Full Saturation of Vinylarenes with Cooperative Homogeneous and Heterogeneous Rhodium Catalysis

Homogeneous and heterogeneous catalyzed reactions can seldom operate synergistically under the same conditions. Here we communicate the use of a single rhodium precursor that acts in both the homogeneous and heterogeneous phases for the asymmetric full saturation of vinylarenes that, to date, constitute an unmet bottleneck in the field. A simple asymmetric hydrogenation of a styrenic olefin, enabled by a ligand accelerated effect, accounted for the facial selectivity in the consecutive arene hydrogenation. Tuning the ratio between the phosphine ligand and the rhodium precursor controlled the formation of homogeneous and heterogeneous catalytic species that operate without interference from each other. The system is flexible in terms of both the chiral ligand and the nature of the external olefin. We anticipate that our findings will promote the development of asymmetric arene hydrogenations.

Deconstructive Oxygenation of Unstrained Cycloalkanamines

A deconstructive oxygenation of unstrained primary cycloalkanamines has been developed for the first time using an auto-oxidative aromatization promoted C(sp3)?C(sp3) bond cleavage strategy. This metal-free method involves the substitution reaction of cycloalkanamines with hydrazonyl chlorides and subsequent auto-oxidative annulation to in situ generate pre-aromatics, followed by N-radical-promoted ring-opening and further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines, and peptides, as well as steroids.