1005002-00-5

Basic information

• Product Name: (R)-2-amino-2-[4-(nonafluorobutanesulfonyloxy)phenyl]-1,1-diphenylethanol
• Synonyms: (R)-2-amino-2-[4-(nonafluorobutanesulfonyloxy)phenyl]-1,1-diphenylethanol
• CAS NO: 1005002-00-5
• Molecular Weight: 587.463
• Mol File: 1005002-00-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-amino-2-[4-(nonafluorobutanesulfonyloxy)phenyl]-1,1-diphenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-amino-2-[4-(nonafluorobutanesulfonyloxy)phenyl]-1,1-diphenylethanol(1005002-00-5)
• EPA Substance Registry System: (R)-2-amino-2-[4-(nonafluorobutanesulfonyloxy)phenyl]-1,1-diphenylethanol(1005002-00-5)

Safety Data

• Hazardous Substances Data: 1005002-00-5(Hazardous Substances Data)

Upstream product

• 1005002-02-7 (R)-2-amino-2-(4-hydroxyphenyl)-1,1-diphenylethanol 
• 375-72-4 Nonafluorobutanesulfonyl fluoride 
• 57591-61-4 methyl (R)-2-amino-2-(4-hydroxyphenyl)acetate hydrochloride 
• 108-86-1 bromobenzene 

Relevant articles and documents

4-Hydroxyphenylglycine-based oxazaborolidines for enantioselective reductions of ketones

Amino alcohols 6 featuring the diphenyl-hydroxymethyl group are prepared from the commercial amino acid (R)-4-hydroxyphenylglycine 3. Oxazaborolidines generated in situ from the amino alcohols 6 and borane-dimethyl sulfide serve as catalysts in enantioselective reductions of acetophenone. The para-substituents of the phenyl ring at the stereogenic carbon atom have a substantial influence on the enantioselectivity. When mediated by the nonaflate 6d, the reduction of ketones 7, 9, 11, and 13 leads to the carbinols 8, 10, 12, and 14 in 90 to 96% ee.