1005326-26-0

Basic information

• Product Name: 1H-Pyrrole-2-carboxylic acid, 3-aMino-5-Methyl-, ethyl ester
• Synonyms: 1H-Pyrrole-2-carboxylic acid, 3-aMino-5-Methyl-, ethyl ester;ethyl 3-aMino-5-Methyl-1H-pyrrole-2-carboxylate
• CAS NO: 1005326-26-0
• Molecular Formula: C8H12N2O2
• Molecular Weight: 168.19308
• EINECS: 937-359-6
• Mol File: 1005326-26-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 85-87 °C
• Boiling Point: 324.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.195±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 16.66±0.50(Predicted)
• CAS DataBase Reference: 1H-Pyrrole-2-carboxylic acid, 3-aMino-5-Methyl-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-2-carboxylic acid, 3-aMino-5-Methyl-, ethyl ester(1005326-26-0)
• EPA Substance Registry System: 1H-Pyrrole-2-carboxylic acid, 3-aMino-5-Methyl-, ethyl ester(1005326-26-0)

Safety Data

• Hazardous Substances Data: 1005326-26-0(Hazardous Substances Data)

Usage

General Description

1H-Pyrrole-2-carboxylic acid, 3-amino-5-methyl-, ethyl ester is a chemical compound that incorporates several chemical structures including a pyrrole ring, a carboxylic acid ester and an amine group. It has potential use in a variety of chemical reactions due to these diverse functional groups. The pyrrole ring can participate in electron-rich aromatic reactions, while the carboxylic acid ester provides an acid-base reactive site and the amine group can act as a nucleophile for a variety of reactions. The specific roles and reactions this compound can participate in would be largely dependent on the reaction conditions such as pH, temperature, and other reactive species present. Additionally, the ethyl ester functional group could potentially be hydrolyzed to produce the parent carboxylic acid, providing another route for chemical transformation.

Upstream product

• 1005326-24-8 diethyl {[(E/Z)-2-cyano-1-methylvinyl]amino}malonate 
• 13433-00-6 diethyl aminomalonate hydrochloride 

Downstream Products

• 41040-24-8 4-chloro-2,6-dimethyl-5H-pyrrolo[3,2-d]pyrimidine 
• 82722-95-0 2,6-dimethyl-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one 
• 1268511-81-4 7-Bromo-4-chloro-2,6-dimethyl-5H-pyrrolo[3,2-d]pyrimidine 
• 2227425-05-8 (S)-3-chloro-7-(2-(hydroxymethyl)morpholino)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile 
• 2227425-05-8 (R)-3-chloro-7-(2-(hydroxymethyl)morpholino)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile 
• 1375065-56-7 7-hydroxy-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile 
• 1268521-89-6 7-chloro-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile 

Relevant articles and documents

Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1)

Sodium-phosphate cotransporter 2a, or NaPi2a (SLC34A1), is a solute-carrier (SLC) transporter located in the kidney proximal tubule that reabsorbs glomerular-filtered phosphate. Inhibition of NaPi2a may enhance urinary phosphate excretion and correct maladaptive mineral and hormonal derangements associated with increased cardiovascular risk in chronic kidney disease-mineral and bone disorder (CKD-MBD). To date, only nonselective NaPi inhibitors have been described. Herein, we detail the discovery of the first series of selective NaPi2a inhibitors, resulting from optimization of a high-throughput screening hit. The oral PK profile of inhibitor PF-06869206 (6f) in rodents allows for the exploration of the pharmacology of selective NaPi2a inhibition.

Fused ring compound and use thereof

The present invention provides a compound represented by the formula: wherein the symbols are as described in the specification, or a salt thereof, which is useful for preventing/treating eicosanoid-associated diseases such as atherosclerosis, diabetes, obesity, atherothrombosis, asthma, fever, pain, cancer, rheumatism, osteoarthritis and atopic dermatitis, and which has an excellent pharmacological action, physicochemical properties, etc.