1005402-49-2Relevant articles and documents
Synthesis and structure-activity relationship of 5-pyridazin-3-one phenoxypiperidines as potent, selective histamine H3 receptor inverse agonists
Tao, Ming,Aimone, Lisa D.,Gruner, John A.,Mathiasen, Joanne R.,Huang, Zeqi,Lyons, Jacquelyn,Raddatz, Rita,Hudkins, Robert L.
, p. 1073 - 1077 (2012/03/11)
Optimization of the R2 and R6 positions of (5-{4-[3-(R)-2-methylpyrrolin-1-yl-propoxy]phenyl}-2H-pyridazin-3-one) 2a with constrained phenoxypiperidines led to the identification of 5-[4-(cyclobutyl- piperidin-4-yloxy)-phenyl]-6-meth