100609-91-4

Basic information

• Product Name: 4-Morpholineacetic acid, a-phenyl-, methyl ester
• CAS NO: 100609-91-4
• Molecular Formula: C13H17NO3
• Molecular Weight: 235.283
• Mol File: 100609-91-4.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 4-Morpholineacetic acid, a-phenyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholineacetic acid, a-phenyl-, methyl ester(100609-91-4)
• EPA Substance Registry System: 4-Morpholineacetic acid, a-phenyl-, methyl ester(100609-91-4)

Safety Data

• Hazardous Substances Data: 100609-91-4(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 7476-66-6 methyl 2-chloro-2-phenylethanoate 
• 4870-65-9 2-bromophenylacetic acid 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 22979-35-7 Methyl phenyldiazoacetate 
• 101-41-7 benzeneacetic acid methyl ester 
• 23328-69-0 4-chloromorpholine 
• 82700-21-8 tert-Butyl-((E)-1-methoxy-2-phenyl-vinyloxy)-dimethyl-silane 
• 40195-27-5 (1-methoxy-2-phenylvinyloxy)trimethylsilane 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 213339-69-6 1-(triisopropylsilyloxy)-1-methoxy-2-phenylethylene 
• 4358-87-6 (RS)-methyl mandelate 
• 298-12-4 Glyoxilic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 91641-50-8 2-morpholino-2-phenylacetic acid hydrochloride 
• 875648-41-2 N-methoxy-N-methyl-2-morpholin-4-yl-2-phenylacetamide 
• 27590-63-2 Triaryethanolamine 
• 1228305-12-1 C₁₄H₂₁NO₂ 
• 31490-21-8 2-(morpholin-4-yl-phenyl-methyl)-1H-benzoimidazole 
• 897446-40-1 N-(2-aminophenyl)-2-morpholin-4-yl-2-phenylacetamide 
• 6342-19-4 morpholin-4-yl(phenyl)acetic acid 

Relevant articles and documents

Insertion of carbenoids into X-H bonds catalyzed by the cyclobutadiene rhodium complexes

The cyclobutadiene rhodium complex [(C4Et4)RhCl]2 (generated from [(C4Et4)Rh(p-xylene)]PF6 and BnNEt3Cl) catalyzes the reaction of methyl α-diazophenylacetate with RnX

Synthesis of Overloaded Cyclopentadienyl Rhodium(III) Complexes via Cyclotetramerization of tert-Butylacetylene

Herein we describe the synthesis and reactivity of rhodium catalysts with the very bulky cyclopentadienyl ligand C8H3tBu4 (designated as tBu4Cp). The reaction of [Rh(cod)Cl]2 with tert-butylacetylene in the presence of Et3N gives the complex (tBu4Cp)Rh(cod) (60-65% yield), in which the cyclopentadienyl ligand tBu4Cp is assembled from four alkyne molecules. The oxidation of (tBu4Cp)Rh(cod) with chlorine or bromine gives the corresponding halide complexes (tBu4Cp)RhX2 (X = Cl (85%), Br (95%)), which have unusual 16-electron monomeric structures due to the steric shielding provided by tBu groups. A similar reaction with iodine gives the ionic dinuclear complex [(tBu4Cp)RhI3Rh(tBu4Cp)]I (99%) with halide bridges. The bromide complex (tBu4Cp)RhBr2 reacts with phosphorus ligands such as P(OMe)3, P(OPh)3, PMe2Ph, and PMePh2 to give the 18-electron adducts (tBu4Cp)RhBr2(PR3), but no reaction occurs with larger phosphines such as PPh3. The racemic chloride (tBu4Cp)RhCl2 can be separated into enantiomers by preparative TLC of its diastereomeric adducts with (R)-phenylglycinol. The complex (tBu4Cp)RhBr2 catalyzes C-H activation and annulation of O-pivaloyl-hydroxamate as well as insertion of phenyldiazoacetate into E-H bonds, although the reaction rates and the substrate scope are limited by the bulky tBu4Cp ligand.

A five coordination Cu(II) cluster-based MOF and its application in the synthesis of pharmaceuticals: Via sp3 C-H/N-H oxidative coupling

Herein, a copper metal-organic framework, termed as VNU-18, containing penta-coordinated sites was successfully synthesized and fully characterized. This material was demonstrated to be an efficient heterogeneous catalyst for the oxidative C-H activation via N-H bonds. The optimized conditions are applicable for the synthesis of pharmaceuticals constructed by α-amino carbonyl skeletons.