100614-09-3

Basic information

• Product Name: 1-(2-bromo-4,5-dimethoxyphenyl)pentan-3-one
• Synonyms: 1-(2-bromo-4,5-dimethoxyphenyl)pentan-3-one
• CAS NO: 100614-09-3
• Molecular Weight: 301.18
• Mol File: 100614-09-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-bromo-4,5-dimethoxyphenyl)pentan-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-bromo-4,5-dimethoxyphenyl)pentan-3-one(100614-09-3)
• EPA Substance Registry System: 1-(2-bromo-4,5-dimethoxyphenyl)pentan-3-one(100614-09-3)

Safety Data

• Hazardous Substances Data: 100614-09-3(Hazardous Substances Data)

Upstream product

• 52679-49-9 3-(2'-bromo-4',5'-dimethoxyphenyl)propionic acid 
• 925-90-6 ethylmagnesium bromide 

Relevant articles and documents

Design, synthesis and biological evaluation of substituted (+)-SG-1 derivatives as novel anti-HIV agents

SG-1 was previously identified as a potent Non-nucleoside reverse transcriptase inhibitors (NNRTI) which works through inhibition of reverse transcriptase (RT) RNA-dependent DNA polymerase activity via a direct binding event. To further investigate the relationship between its structure and activity, four series of novel analogues were designed and synthesized with 12 of them inhibiting HIV-1 replication with IC50s in the range 0.09–6.71 μM. Compound 4b, 4c, 4f, 2 and 6b were further tested on two NNRTI-resistant HIV-1 strains and one NNRTI-resistant superbug. The result showed that RT- E138K/M184V mutant virus conferred 4.7–9.1-fold resistance to 4c, 4f, 2 and 6b, but only showed slight resistance to 4b (2-fold) which was better than SG-1.