100634-97-7

Basic information

• Product Name: 5-phenylsulfanyl-2'-deoxyuridine
• Synonyms: 5-phenylsulfanyl-2'-deoxyuridine
• CAS NO: 100634-97-7
• Molecular Weight: 336.368
• Mol File: 100634-97-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-phenylsulfanyl-2'-deoxyuridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenylsulfanyl-2'-deoxyuridine(100634-97-7)
• EPA Substance Registry System: 5-phenylsulfanyl-2'-deoxyuridine(100634-97-7)

Safety Data

• Hazardous Substances Data: 100634-97-7(Hazardous Substances Data)

Upstream product

• 65505-76-2 C⁵-chloromercuri-2'-deoxyuridine 
• 882-33-7 diphenyldisulfane 
• 54-42-2 5-Iodo-2'-deoxyuridine 
• 59-14-3 5-bromo-2'-deoxyuridine 
• 108-98-5 thiophenol 
• 1192-40-1 copper(I) thiophenolate 

Downstream Products

• 212075-44-0 1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-5-phenylsulfanyl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Copper-mediated arylsulfanylations and arylselanylations of pyrimidine or 7-deazapurine nucleosides and nucleotides

The syntheses of 5-arylsulfanyl- or 5-arylselanylpyrimidine and 7-arylsulfanyl- or 7-arylselanyl-7-deazapurine nucleosides and nucleotides were developed by the Cu-mediated sulfanylations or selanylations of the corresponding 5-iodopyrimidine or 7-iodo-7-

Facile photocyclization chemistry of 5-phenylthio-2′-deoxyuridine in duplex DNA

We report here the synthesis of 5-phenylthio-2′-deoxyuridine (d PhSU), its incorporation into oligodeoxynucleotides (ODNs), and its photocyclization chemistry. Irradiation of dinucleoside monophosphate d( PhSUG) and dPhSU-

Palladium-Mediated Synthesis of C-5 Pyrimidine Nucleoside Thioethers from Disulfides and Mercurinucleosides

Thioether-linked side chains can be created at C-5 of pyrimidine nucleosides via a palladium-mediated reaction of mercurated nucleosides with organic disulfides. 5-(Chloromercuri)-2'-deoxyuridine reacts with butyl disulfide, phenyl disulfide, dimethyl 3,3'-dithiopropionate, and N,N'-bis(trifluoroacetyl)cystamine to yield respectively 5-(1-thiapentyl)-2'-deoxyuridine, 5-(phenylthio)-2'-deoxyuridine, 5--2'-deoxyuridine, and 5--2'-deoxyuridine in yields ranging from 46 to 73percent.Other mercurated nucleosides, including 5-(chloromercuri)-2'-deoxycytidine, 5-(chloromercuri)cytidine, and 5-(chloromercuri)tubercidin react with N,N'-bis(trifluoroacetyl)cystamine and lithium-palladium chloride in methanol to yield the corresponding coupled products, but the yields are much lower (5-10percent).The nucleoside coupling reaction is complicated by competing side reactions between disulfides and Pd2+, which remain to be elucidated