1006364-88-0

Basic information

• Product Name: methyl 5-(trifluoromethyl)-6-oxo-1,6-dihydropyridine-2-carboxylate
• CAS NO: 1006364-88-0
• Molecular Weight: 221.136
• Mol File: 1006364-88-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl 5-(trifluoromethyl)-6-oxo-1,6-dihydropyridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-(trifluoromethyl)-6-oxo-1,6-dihydropyridine-2-carboxylate(1006364-88-0)
• EPA Substance Registry System: methyl 5-(trifluoromethyl)-6-oxo-1,6-dihydropyridine-2-carboxylate(1006364-88-0)

Safety Data

• Hazardous Substances Data: 1006364-88-0(Hazardous Substances Data)

Upstream product

• 1415899-18-1 1-oxy-5-trifluoromethyl-pyridine-2-carboxylic acid methyl ester 
• 124236-37-9 5-(trifluoromethyl)-pyridine-2-carboxylic acid methyl ester 
• 80194-69-0 5-(trifluoromethyl)picolinic acid 
• 1006364-87-9 methyl 1-benzyloxy-5-(trifluoromethyl)-6-oxo-1,2,3,6-tetrahydropyridine-2-carboxylate 

Relevant articles and documents

THIAZALOPYRROLIDINE INHIBITORS OF ROR-GAMMA

Provided are novel compounds of Formula (I): pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by ROR?. Also provided are pharmaceutical compositions comprising the novel compounds of Formula (I) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders.

A metathesis-based approach to the synthesis of 2-pyridones and pyridines

(Chemical Equation Presented) The ring-closing metathesis reaction has been successfully employed to form a range of dihydropyridone intermediates, which are in the correct oxidation state to undergo a base-induced elimination to reveal the aromatic 2-pyridone. This mild and novel approach to six-membered heteroaromatic compounds then provides access to a wide variety of substituted pyridines in excellent overall yield.