100638-27-5Relevant articles and documents
Thiazine (or oxazine) derivatives and preparation thereof
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, (2008/06/13)
Thiazine derivatives of the formula [I]: STR1 wherein R1, R2, R4 and R5 are each hydrogen atom; R3 is hydrogen atom or a halogen atom; X is sulfur atom; R6 is naphthyl, a sulfur-containing monoheterocyclic group or a substituted phenyl; Z1 is two hydrogen atoms; Z2 is oxygen atom; A is a lower alkylene; R7 and R8 are the same or different and are each i) hydrogen atom, ii) a lower alkyl, iii) a lower alkenyl, iv) a lower alkynyl, or v) a lower alkyl which is substituted by a substituted phenyl, or both form together with the adjacent nitrogen atom a nitrogen-containing monoheterocyclic group; except for the compound [I] wherein R1, R2, R3, R4 and R5 are each hydrogen atom, X is sulfur atom, R6 is a halogenophenyl, Z1 is two hydrogen atoms, Z2 is oxygen atom, A is a lower alkylene, R7 and R8 are the same or different and each a lower alkyl; or a pharmaceutically acceptable salt thereof, which have calcium antagonistic activity within the cerebral tissues and are useful for prophylaxis and treatment of ischemic encephalopathia.
A Convenient and General Synthesis of 2-Aryl- and 2-Pyridyl-3-oxo-3,4-dihydro-2H-1,4-benzothiazines
Jacobsen, Niels,Kolind-Andersen, Hans
, p. 911 - 914 (2007/10/02)
The reaction of bis(2-aminophenyl) disulphide 1 with methyl or ethyl aryl- or pyridylacetates and sodium hydride gives the title compounds in good yield and high purity.The reaction is general, the starting materials easily available and the workup is simple and rapid.
