1006614-50-1Relevant articles and documents
Preparation method of phenyl-containing compound
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Paragraph 0106-0111, (2022/01/04)
The present invention discloses a method for preparing an phenyl-containing compound. The present invention provides a method for preparing a compound shown in formula I, comprising the following steps: in the presence of formamide or acetamide, in the pr
Preparation method of ticagrelor key intermediate
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Paragraph 0013, (2020/05/08)
The invention belongs to the technical field of medicines, and particularly relates to a preparation method of a ticagrelor key intermediate, and the method is used for preparing the ticagrelor intermediate, has the advantages of short reaction steps, mild reaction conditions and higher yield than the existing preparation method, is economical and effective, and is suitable for large-scale industrial production.
Intermediate for preparing ticagrelor and preparation method of intermediate
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Paragraph 0074; 0075, (2018/10/11)
The invention discloses an intermediate for preparing ticagrelor. A chemical structure of the intermediate is shown by the formula (II) as shown in the description. A preparation method of the intermediate comprises: 3,4-difluorostyrene is subjected to a addition-cyclization reaction to obtain a compound (II). The invention also discloses the preparation method of a compound shown as a chemical structural formula (III), and the preparation method comprises: the compound (II) is subjected to a rearrangement reaction to obtain a compound (III), and the chemical structural formula (III) is shownin the description. The invention further discloses the preparation method of a compound shown as a chemical structural formula (IV), wherein the compound (III) is rearranged and resolved to obtain acompound (IV), and the chemical structural formula (IV) is shown in the description. By using the compound (II) as a key intermediate, a synthetic route of synthesis of the ticagrelor can be greatly shortened, and the compound (III) and the compound (IV) can be further synthesized. The synthetic route is short and novel, mild in reaction condition, high in yield, economical, effective, and suitable for large-scale industrial production.