1007206-27-0

Basic information

• Product Name: 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine
• Synonyms: 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine;1. 4-(4,6-dichloro-5-(2-chloroethyl)pyrimidin-2-yl)morpholine
• CAS NO: 1007206-27-0
• Molecular Formula: C₁₀H₁₂Cl₃N₃O
• Molecular Weight: 297
• Mol File: 1007206-27-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine(1007206-27-0)
• EPA Substance Registry System: 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine(1007206-27-0)

Safety Data

• Hazardous Substances Data: 1007206-27-0(Hazardous Substances Data)

Usage

General Description

4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine is a chemical compound that belongs to the class of pyrimidine derivatives. It contains two chlorine atoms and an ethyl group attached to a pyrimidine ring, as well as a morpholine ring. 4-(4,6-dichloro-5-(2-chloroethyl)pyriMidin-2-yl)Morpholine has potential biological activity and is often used as a building block in the synthesis of pharmaceuticals and agrochemicals. It may also have applications in the field of medicinal chemistry and drug discovery research. The compound's structure and properties make it an important molecule for further investigation and potential use in various scientific and industrial applications.

Upstream product

• 127915-15-5 2-oxotetrahydrofuran-3-carboxylic acid methyl ester 
• 5638-78-8 morpholinoformamidine hydrochloride 
• 1178564-17-4 5-(2-hydroxyethyl)-2-morpholin-4-yl-pyrimidine-4,6-diol 
• 157415-17-3 Morpholine-4-carboxamidine; hydrobromide 

Downstream Products

• 1007215-39-5 6-chloro-5-(2-chloroethyl)-N-[(4-methoxyphenyl)methyl]-2-morpholinopyrimidin-4-amine 
• 1178564-27-6 4-chloro-7-methanesulfonyl-2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 
• 1007206-24-7 4-(4-chloro-7-(pyridin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-yl)morpholine 
• 1007207-67-1 CH5132799 
• 1007206-29-2 bis-(4-methoxybenzyl)-[5-(2-morpholin-4-yl-7-pyridin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine 
• 1007208-63-0 [3-[4-[2-[bis[(4-methoxyphenyl)methyl]amino]pyrimidin-5-yl]-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]phenyl]-(4-methylpiperazin-1-yl)methanone 
• 1007208-13-0 4-[4-[2-[bis[(4-methoxyphenyl)methyl]amino]pyrimidin-5-yl]-2-morpholino-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]benzaldehyde 
• 1007209-85-9 5-[2-morpholino-7-[4-(morpholinomethyl)phenyl]-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl]pyrimidin-2-amine 
• 1007208-40-3 [4-[4-(2-aminopyrimidin-5-yl)-2-morpholino-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]phenyl]-(4-methylpiperazin-1-yl)methanone 
• 1007210-13-0 [4-(4-{2-[bis-(4-methoxy-benzyl)-amino]-pyrimidin-5-yl}-2-morpholin-4-yl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-phenyl]-(4-methyl-piperazin-1-yl)-methanone 
• 1007208-67-4 5-(2-morpholino-7-phenyl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine 
• 1007207-65-9 N,N-bis[(4-methoxyphenyl)methyl]-5-(2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine 
• 1007208-62-9 [3-[4-(2-aminopyrimidin-5-yl)-2-morpholino-5,6-dihydropyrrolo[2,3-d]pyrimidin-7-yl]phenyl]-(4-methylpiperazin-1-yl)methanone 

Relevant articles and documents

BICYCLIC HETEROARENES AND METHODS OF THEIR USE

Disclosed are compounds useful in the treatment of neurological disorders. The compounds described herein, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological diseases.

Lead optimization of a dihydropyrrolopyrimidine inhibitor against phosphoinositide 3-kinase (PI3K) to improve the phenol glucuronic acid conjugation

Our lead compound for a phosphoinositide 3-kinase (PI3K) inhibitor (1) was metabolically unstable because of rapid glucuronidation of the phenol moiety. Based on structure-activity relationship (SAR) information and a FlexSIS docking simulation score, aminopyrimidine was identified as a bioisostere of phenol. An X-ray structure study revealed a hydrogen bonding pattern of aminopyrimidine derivatives. Finally, aminopyrimidine derivatives 33 showed strong tumor growth inhibition against a KPL-4 breast cancer xenograft model in vivo.

PYRROLOPYRIMIDIN DERIVATIVE FOR USE AS PI3K INHIBITOR, AND USE THEREOF

A preventive or therapeutic agent of a proliferative disease such as cancer, having superior PI3K inhibitory effects, superior cell proliferation inhibitory action as well as superior stability in a body and water solubility, is provided. A compound represented by formula (I): [wherein, Q represents a linking group represented by -X-Y-; X represents a single bond -CO-, -CONH-, -CON(C1-4 alkyl)-, -CS-, -CSNH-, -CSN(C1-4 alkyl)-, or -SO2-; Y represents a single bond, arylene or heteroarylene; provided that X and Y are not simultaneously single bonds; and R1 represents -C0-6 alkylene-(A)m-C1-6 alkyl, or C0-6 alkylene-(A)m-C0-6 alkylene-(heterocycle)] or a pharmaceutically acceptable salt thereof.