1007882-12-3Relevant articles and documents
Development of a Synthesis Process for a Novel HCV NS5A Inhibitor, Emitasvir
An, Delie,Dong, Wanrong,Fang, Qinghong,Feng, Yahui,Huang, Enhuo,Liu, Haiwang,Peng, Zhihong,Xiang, Xuwen,Xie, Hongming,Zhang, Yingjun
, p. 838 - 848 (2021)
A new approach to the synthesis of Emitasvir (DAG181), a small molecule hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor, is described. Enantioselective enzymatic desymmetrization with hydrolases in the synthetical approach can significantly avoid the loss of chiral raw materials in the resolution process. The synthesis route is further optimized and scaled-up to establish a new process that is applied to the preparation of kilogram scales of target active pharmaceutical ingredients (APIs). Compared with our initial process, the overall yield of target API was dramatically improved from 17 to 40%.
DICARBAMATE INHIBITORS OF NS5A FOR TREATMENT OF HEPATITIS C VIRUS INFECTIONS AND RELATED DISEASES
-
, (2020/11/03)
Dicarbamate compounds as inhibitors of NS5A, and therapeutic uses and methods of preparation thereof, are disclosed. These compounds, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodmgs, and pharmaceutical compositions t
Monoglycosyl-containing heterocyclic compound for inhibiting hepatitis C viruses and preparation method
-
, (2019/03/28)
The invention discloses a monoglycosyl-containing heterocyclic compound for inhibiting hepatitis C viruses and a preparation method. The monoglycosyl-containing heterocyclic compound has a chemical structure represented by a formula I shown in the description. The monoglycosyl-containing heterocyclic compound disclosed by the invention can be used for effectively inhibiting protease of the hepatitis C viruses and treating infection of the hepatitis C viruses (HCV).