1008-75-9

Basic information

• Product Name: 3-METHYL-5-PHENYLISOXAZOLE
• Synonyms: Isoxazole, 3-methyl-5-phenyl- (6CI,7CI,8CI,9CI);3-Methyl-5-phenylisoxazole ,97%;5-Phenyl-3-methylisoxazole;3-methyl-5-phenyl-1,2-oxazole;3-methyl-5-phenyloxazole
• CAS NO: 1008-75-9
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.19
• Product Categories: OXAZOLE;Building Blocks;Heterocyclic Building Blocks;Isoxazoles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 1008-75-9.mol
• Article Data: 54

Chemical Properties

• Melting Point: 63-68 °C
• Boiling Point: 262-264 °C/760 mmHg
• Flash Point: 112.7°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0.00668mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.38±0.28(Predicted)
• CAS DataBase Reference: 3-METHYL-5-PHENYLISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-5-PHENYLISOXAZOLE(1008-75-9)
• EPA Substance Registry System: 3-METHYL-5-PHENYLISOXAZOLE(1008-75-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 1008-75-9(Hazardous Substances Data)

Usage

Description

3-METHYL-5-PHENYLISOXAZOLE is an organic compound characterized by its white crystalline structure. It belongs to the class of isoxazoles, which are heterocyclic compounds with a five-membered ring containing two oxygen atoms and one nitrogen atom. This specific compound features a methyl group at the third position and a phenyl group at the fifth position, which may contribute to its unique chemical properties and potential applications.

Uses

Used in Pharmaceutical Industry:
3-METHYL-5-PHENYLISOXAZOLE is used as an Aminopeptidase A inhibitor for its potential therapeutic applications. Aminopeptidase A is an enzyme that plays a role in various biological processes, and its inhibition can be beneficial in treating certain conditions. By targeting this enzyme, 3-METHYL-5-PHENYLISOXAZOLE may contribute to the development of new drugs or therapies in the pharmaceutical industry.
Additionally, due to its white crystalline structure and chemical properties, 3-METHYL-5-PHENYLISOXAZOLE may have other potential applications in different industries, such as in the synthesis of other compounds or as an intermediate in chemical reactions. However, more information would be needed to determine its specific uses in these areas.

InChI:InChI=1/C10H9NO/c1-8-7-10(12-11-8)9-5-3-2-4-6-9/h2-7H,1H3

Upstream product

• 64-18-6 formic acid 
• 53120-17-5 1-phenyl-1,3-pentanedionedioxime 
• 78664-25-2 N-(1-Hydroxyimino-1-phenyl-3-butyl)hydroxylamine 
• 859809-89-5 N-hydroxy-N-(1-methyl-3-oxo-3-phenyl-propyl)-formamide 
• 3163-99-3 3-methoxycarbonyloxy-1-phenyl-but-2-en-1-one 
• 22606-42-4 hydroxylamine acetate 
• 14088-41-6 4-amino-4-phenyl-3-buten-2-one 
• 53009-46-4 3-(hydroxyimino-(seqcis))-1-phenyl-butanone-⁽¹⁾ 
• 93-91-4 1-phenylbutan-1,3-dione 
• 17153-21-8 3-methyl-5-phenyl-isoxazole-4-carboxylic acid 
• 1817-57-8 4-phenyl-3-butyne-2-one 
• 16114-49-1 (3-methyl-5-phenyl-isoxazol-4-yl)-boronic acid 
• 7157-78-0 5-(1-Cyclohexenyl)-3-methylisoxazole 
• 79-24-3 Nitroethane 

Downstream Products

• 52063-44-2 3-methyl-5-(4-nitrophenyl)isoxazole 
• 23652-90-6 3-amino-1-phenylbut-2-en-1-one 
• 56426-41-6 3-methyl-5-phenylpyrazole 
• 59997-49-8 Verbdg_. s.n.F 
• 59997-50-1 (E)-3-tert-Butoxy-3-methylamino-1-phenyl-propenone 
• 1846-33-9 N-phenacylacetamide 
• 197852-01-0 N-methyl-3-oxo-3-phenylpropanamide 
• 26346-42-9 3,4-dichloro-3-methyl-5-phenyl-3H-isoxazol-2-ol 
• 80949-39-9 4,4-Dichloro-5-methoxy-3-methyl-5-phenyl-4,5-dihydro-isoxazole 
• 14633-16-0 3-pentyl-5-phenylisoxazole 
• 142231-19-4 4-butyl-3-methyl-5-phenylisoxazole 
• 142231-20-7 4-butyl-3-pentyl-5-phenylisoxazole 
• 55342-86-4 3-(1-hydroxycyclohexyl)methyl-5-phenylisoxazole 
• 142231-18-3 4-benzyl-3-methyl-5-phenylisoxazole 

Relevant articles and documents

Convenient synthesis of 3,5-disubstituted isoxazoles

α,β-Unsaturated oximes obtained from the corresponding α,β-unsaturated ketones on treatment with 2 equivalents of manganese dioxide in refluxing chloroform gives 3,5-disubstituted isoxazoles in good yields. Copyright Taylor & Francis Group, LLC.

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An improved method for preparation of nitrile oxides from nitroalkanes for in situ dipolar cycloadditions

A new method has been found for generation of nitrile oxides in situ from nitroalkanes under mild conditions. Thus, reaction of nitroalkanes 1 with di-tert-butyl dicarbonate (2) and 4-dimethylaminopyridine (3) as catalyst in the presence of dipolarophiles

A photochemical one-pot three-component synthesis of tetrasubstituted imidazoles

Tetrasubstituted imidazoles can be formed in a photochemical one-pot synthesis from aldehydes, α-aminonitriles, and isoxazoles. Condensation of the first two components produces α-(alkylideneamino)nitriles which react under basic conditions with the acylazirines formed in situ by photochemical ring transformation of the isoxazole component. This process includes an unusual cleavage of the C2-C3 bond of the acylazirine. The reaction mechanism was studied by DFT calculations. (Chemical Equation Presented)

Synthesis of isoxazole derivatives by means of O-acylation of aliphatic nitro compounds in the presence of acetylenic compounds

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NHC-palladium-catalyzed ionic liquid-accelerated regioselective oxyarylation of alkynes with diaryl ethers?

The first NHC-palladium-catalyzed regioselective oxyarylation of oxime ether in a task-specific ionic liquid via C(sp3)-O and C(sp2)-O bond cleavage of two different types of ethers for the assembly of structurally diverse 4-arylisoxazoles is described. Both the basic ionic liquid [C3NH2mim]Br and NHC-Pd catalyst IPr-Pd-Im-Cl2 played an important role in this transformation. Notably, this new approach provides a practical and straightforward route to access a broad range of privileged 4-arylisoxazole structures with good yields and excellent regioselectivities. Significantly, this catalytic system can be recycled up to eight times without significant loss of catalytic activity.

A Reusable CNT-Supported Single-Atom Iron Catalyst for the Highly Efficient Synthesis of C?N Bonds

C?N bond formation is regarded as a very useful and fundamental reaction for the synthesis of nitrogen-containing molecules in both organic and pharmaceutical chemistry. Noble-metal and homogeneous catalysts have frequently been used for C?N bond formatio