1008402-47-8

Basic information

• Product Name: Mal-PEG3-Mal
• Synonyms: Mal-PEG3-Mal;Bis-Mal-PEG3
• CAS NO: 1008402-47-8
• Molecular Formula: C22H30N4O9
• Molecular Weight: 494.495
• EINECS: -0
• Product Categories: Homobifunctional PEG
• Mol File: 1008402-47-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 791.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.319±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility: Chloroform (Very Slightly), DMSO (Slightly, Sonicated)
• PKA: 14.70±0.46(Predicted)
• CAS DataBase Reference: Mal-PEG3-Mal(CAS DataBase Reference)
• NIST Chemistry Reference: Mal-PEG3-Mal(1008402-47-8)
• EPA Substance Registry System: Mal-PEG3-Mal(1008402-47-8)

Safety Data

• Hazardous Substances Data: 1008402-47-8(Hazardous Substances Data)

Usage

Description

Mal-PEG3-Mal, also known as Bis-Mal-PEG3, is a PEG (polyethylene glycol) derivative that features two maleimide groups. These maleimide groups can react with thiol groups to form a covalent bond, allowing the attachment of biomolecules with a thiol group. The hydrophilic PEG spacer enhances solubility in aqueous media, making it a versatile molecule for various applications.

Uses

Used in Bioconjugation:
Mal-PEG3-Mal is used as a PEG linker for bioconjugation applications. The maleimide groups facilitate the covalent attachment of biomolecules with thiol groups, such as proteins, peptides, or other thiol-containing molecules, to form stable and soluble conjugates.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Mal-PEG3-Mal is used as a drug delivery enhancer. The PEG spacer improves the solubility and stability of drug molecules, reducing their immunogenicity and increasing their circulation time in the body. This can lead to improved therapeutic efficacy and reduced side effects.
Used in Diagnostics:
Mal-PEG3-Mal can be used as a component in the development of diagnostic tools, such as imaging agents or biosensors. The PEG spacer can help improve the solubility and biocompatibility of these diagnostic agents, enhancing their performance and reducing potential side effects.
Used in Material Science:
In material science, Mal-PEG3-Mal can be utilized in the development of biocompatible materials, such as hydrogels or coatings for medical devices. The PEG spacer can improve the biocompatibility and reduce the risk of immune responses or inflammation when these materials come into contact with biological systems.
Overall, Mal-PEG3-Mal is a versatile PEG derivative with a wide range of applications in various industries, including bioconjugation, pharmaceuticals, diagnostics, and material science, due to its ability to form covalent bonds with thiol-containing biomolecules and improve solubility and biocompatibility.