1008757-24-1

Basic information

• Product Name: 5-hexyl-2-methyl-1,4-di(p-toluenesulfonyl)-1,2,3,4-tetrahydropyrazine
• Synonyms: 5-hexyl-2-methyl-1,4-di(p-toluenesulfonyl)-1,2,3,4-tetrahydropyrazine
• CAS NO: 1008757-24-1
• Molecular Weight: 490.688
• Mol File: 1008757-24-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-hexyl-2-methyl-1,4-di(p-toluenesulfonyl)-1,2,3,4-tetrahydropyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hexyl-2-methyl-1,4-di(p-toluenesulfonyl)-1,2,3,4-tetrahydropyrazine(1008757-24-1)
• EPA Substance Registry System: 5-hexyl-2-methyl-1,4-di(p-toluenesulfonyl)-1,2,3,4-tetrahydropyrazine(1008757-24-1)

Safety Data

• Hazardous Substances Data: 1008757-24-1(Hazardous Substances Data)

Upstream product

• 38761-67-0 1-bromo-1-octyne 
• 89990-51-2 4-methyl-N-(1-methyl-2-{[(4-methylphenyl)sulfonyl]amino}ethyl)benzenesulfonamide 

Relevant articles and documents

Copper-catalyzed 1,2-double amination of 1-halo-1-alkynes. Concise synthesis of protected tetrahydropyrazines and related heterocyclic compounds

Reaction of N,N′-di(p-toluenesulfonyl)-1,2-diamine, 1-bromo-1-alkyne, K3PO4, and a catalytic amount of CuI in hot DMF afforded N,N′-di(p-toluenesulfonyl)-1,2,3,4-tetrahydropyrazines in good yields. The reaction most likely involves (i) monoalkynylation of the diamine derivative with 1-bromo-1-alkyne, and (ii) 6-endo-dig ring closure between the acetylenic bond and another sulfonylamine moiety of the diamine. When the starting 1,2-diamine derivative was replaced with N,N′-di(p-toluenesulfonyl)-1,3-diamine or N-(p-toluenesulfonyl)-2-amino-1-ethanol, the corresponding seven-membered diazacycle or six-membered N,O-heterocycle was produced. In addition, 1,1-dibromo-1-alkene could be used in place of 1-bromo-1-alkyne. Copyright