1009083-66-2Relevant articles and documents
P2Y1 receptor antagonists as novel antithrombotic agents
Pfefferkorn, Jeffrey A.,Choi, Chulho,Winters, Thomas,Kennedy, Robert,Chi, Liguo,Perrin, Lisa A.,Lu, Gina,Ping, Yun-Wen,McClanahan, Tom,Schroeder, Richard,Leininger, Michael T.,Geyer, Andrew,Schefzick, Sabine,Atherton, James
body text, p. 3338 - 3343 (2009/04/06)
The P2Y1 and P2Y12 purinergic receptors are responsible for mediating adenosine diphosphate (ADP) dependent platelet aggregation. Evidence from P2Y1 knockout studies as well as from nucleotide-based small molecule P2Y1 antagonists has suggested that the antagonism of this receptor may offer a novel and effective method for the treatment of thrombotic disorders. Herein, we report the identification and optimization of a series of non-nucleotide P2Y1 antagonists that are potent and orally bioavailable.