100927-10-4 Usage
Description
Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI), also known as (R)-1-Aminopropan-2-ylcarbamic Acid tert-Buty Ester, is a chemical compound with a unique molecular structure. It is characterized by the presence of a carbamic acid group, an amino group, and a 1,1-dimethylethyl ester group. Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI) is a chiral molecule, with the R configuration at the 1-position, which gives it specific properties and potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
Carbamic acid, [(1R)-2-amino-1-methylethyl]-, 1,1-dimethylethyl ester (9CI) is used as an intermediate in the preparation of potent benzothiophene inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2). These inhibitors play a crucial role in the development of drugs targeting various diseases, including inflammatory and autoimmune disorders, as well as cancer.
In the pharmaceutical industry, the compound serves as a key building block for the synthesis of biologically active molecules. Its unique structure allows for the creation of new drugs with improved efficacy and selectivity, making it a valuable asset in drug discovery and development processes.
Additionally, the compound's chiral nature makes it an interesting target for research in asymmetric synthesis and chiral chemistry. This can lead to the development of more efficient and environmentally friendly synthetic routes to produce enantiomerically pure compounds, which are essential for the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 100927-10-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,9,2 and 7 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 100927-10:
(8*1)+(7*0)+(6*0)+(5*9)+(4*2)+(3*7)+(2*1)+(1*0)=84
84 % 10 = 4
So 100927-10-4 is a valid CAS Registry Number.
InChI:InChI=1/C8H18N2O2.ClH/c1-6(5-9)10-7(11)12-8(2,3)4;/h6H,5,9H2,1-4H3,(H,10,11);1H/t6-;/m1./s1
100927-10-4Relevant articles and documents
Affinity to the nicotinic acetylcholine receptor and insecticidal activity of chiral imidacloprid derivatives with a methylated imidazolidine ring
Nishiwaki, Hisashi,Nagaoka, Hikaru,Kuriyama, Mituhiro,Yamauchi, Satoshi,Shuto, Yoshihiro
, p. 780 - 782 (2011)
Four imidacloprid derivatives with an asymmetrically methylated imidazolidine ring were synthesized. Their affinity to the nicotinic acetylcholine receptor of housefly Musca domestica and insecticidal activity against the housefly were measured. The compound with a 5R-methylated imidazolidine ring demonstrated intrinsic activity comparable to that of the unsubstituted compound. Most of the compounds were synergized by oxygenase inhibitors.
MK2 INHIBITORS AND USES THEREOF
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Paragraph 0247, (2016/04/09)
The present invention provides compounds, compositions thereof, and methods of using the same.
CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS
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, (2015/10/28)
The subject matter herein is directed to carbazole-containing amide, carbamate, and urea derivatives and pharmaceutically acceptable salts or hydrates thereof of structural formula I wherein the variable R1, R2, R3, R4, R5, R6, R7, A, D, E, G, J, L, M, Q, a, and b are accordingly described. Also provided are pharmaceutical compositions containing the compounds of formula I to treat a Cry-mediated disease or disorder, such as diabetes, complications associated with diabetes, Cushing's syndrome, NASH, NAFLD, asthma, and COPD.
