100960-55-2 Usage
Description
4-Benzoxazolecarboxylic Acid, 2,3-dihydro-2-oxo-, also known as 2-oxo-2,3-dihydro-4-benzoxazole carboxylic acid, is an organic compound with potential applications in various fields, particularly in the pharmaceutical and chemical industries. It is characterized by its unique chemical structure, which includes a benzoxazole ring and a carboxylic acid group.
Uses
Used in Pharmaceutical Industry:
4-Benzoxazolecarboxylic Acid, 2,3-dihydro-2-oxo-, is used as a reagent for biological studies involving phosphodiesterase 4 (PDE4) inhibitors and metabotropic glutamate 5 (mGlu5) receptor antagonists. These compounds play a crucial role in the development of new drugs for various therapeutic applications, such as treating inflammatory diseases, neurological disorders, and other conditions.
As a reagent in biological studies, 4-Benzoxazolecarboxylic Acid, 2,3-dihydro-2-oxo-, aids in the investigation of the mechanisms of action, selectivity, and potential side effects of PDE4 inhibitors and mGlu5 receptor antagonists. This information is vital for the development of more effective and safer drugs targeting these biological pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 100960-55-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,0,9,6 and 0 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 100960-55:
(8*1)+(7*0)+(6*0)+(5*9)+(4*6)+(3*0)+(2*5)+(1*5)=92
92 % 10 = 2
So 100960-55-2 is a valid CAS Registry Number.
100960-55-2Relevant articles and documents
"TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION"
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Page/Page column 92; 136, (2011/10/13)
The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active
Rational design, synthesis, and structure-activity relationship of benzoxazolones: New potent mglu5 receptor antagonists based on the fenobam structure
Ceccarelli, Simona M.,Jaeschke, Georg,Buettelmann, Bernd,Huwyler, Joerg,Kolczewski, Sabine,Peters, Jens-Uwe,Prinssen, Eric,Porter, Richard,Spooren, Will,Vieira, Eric
, p. 1302 - 1306 (2008/09/20)
A novel class of potent and stable mGlu5 receptor antagonists was developed by combining information from a high-throughput screening campaign with the structure of the known anxiolytic fenobam. Representative compounds from this class show favorable phar