1009838-34-9

Basic information

• Product Name: C₁₆H₁₈Cl₂N₂O₂
• CAS NO: 1009838-34-9
• Molecular Weight: 341.237
• Mol File: 1009838-34-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₈Cl₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₈Cl₂N₂O₂(1009838-34-9)
• EPA Substance Registry System: C₁₆H₁₈Cl₂N₂O₂(1009838-34-9)

Safety Data

• Hazardous Substances Data: 1009838-34-9(Hazardous Substances Data)

Upstream product

• 1489-63-0 2-cyclohexylsuccinic acid 
• 13123-92-7 (2,4-dichlorophenyl)hydrazine 

Relevant articles and documents

Synthesis, physicochemical and anticonvulsant properties of new N-phenylamino derivatives of 2-azaspiro[4.4]nonane- and [4.5]decane-1,3-diones: Part V

The synthesis, physicochemical and pharmacological properties of new N-phenylamino derivatives of 2-azaspiro[4.4]nonane-1,3-dione (8-10), 2-azaspiro[4.5]decane-1,3-dione (11-18) and 3-cyclohexyl-pyrrolidine-2,5-dione (19, 20) derivatives were described. The anticonvulsant properties of those compounds were examined by a maximal electroshock (MES) and a pentylenetetrazole (scPTZ) tests, and their neurotoxicity was determined using a rota-rod test. The most active was N-[(2,4-dichlorophenyl)-amino]-2-azaspiro[4.4]nonane-1,3-dione (9), which exhibited anti-seizure properties in the MES model at a dose of 100 mg/kg in mice and at a dose of 30 mg/kg in rats. To explain the possible mechanism of action, for chosen active derivatives N-[(2,4-dichlorophenyl)-amino]-2-azaspiro[4.4]nonane-1,3-dione (9), N-[(4-bromophenyl)-amino]-2-azaspiro[4.4]nonane-1,3-dione (10), N-[(2,4-dichlorophenyl)-amino]-2-azaspiro[4.5]decane-1,3-dione (12) and N-[(4-bromophenyl)-amino]-2-azaspiro[4.5]decane-1,3-dione (13) their influence on GABAA receptors were tested in vitro. Moreover, for all compounds obtained the lipophilic properties were determined by use of RP-HPLC method.