101020-89-7 Usage
Description
Artemisitene is a sesquiterpene lactone derived from the Artemisia annua plant, which is known for its potent antimalarial properties. It is the oxidized form of artemisinin and exists as a minor constituent in an American variant of the plant. Artemisitene is a key precursor in the biosynthesis of artemisinin, along with other compounds such as artemisinic acid and artemisinin B. artemisitene has garnered significant attention for its potential applications in medicine and other industries.
Uses
Used in Pharmaceutical Industry:
Artemisitene is used as an antimalarial agent for its potent activity against Plasmodium parasites, which cause malaria. It is a valuable component in the development of artemisinin-based combination therapies (ACTs), which are the current standard of treatment for malaria.
Used in Drug Synthesis:
Artemisitene serves as an important precursor in the biosynthesis of artemisinin and its derivatives. These compounds have been extensively studied for their potential applications in medicine, including the development of new antimalarial drugs and the treatment of other diseases.
Used in Cosmetic Industry:
Due to its potent antimicrobial and anti-inflammatory properties, artemisitene can be used as an active ingredient in cosmetic products. It may help in the development of skincare formulations that promote healing and protect against harmful microorganisms.
Used in Agricultural Industry:
Artemisitene's antimicrobial properties can also be harnessed in the agricultural sector. It can be used as a natural pesticide or fungicide to protect crops from various diseases and pests, promoting sustainable farming practices.
Check Digit Verification of cas no
The CAS Registry Mumber 101020-89-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,1,0,2 and 0 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 101020-89:
(8*1)+(7*0)+(6*1)+(5*0)+(4*2)+(3*0)+(2*8)+(1*9)=47
47 % 10 = 7
So 101020-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H20O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8,10-11,13H,2,4-7H2,1,3H3/t8-,10+,11?,13-,14-,15-/m1/s1
101020-89-7Relevant articles and documents
Novel spirobicyclic artemisinin analogues (artemalogues): Synthesis and antitumor activities
Liu, Gang,Song, Shanshan,Shu, Shiqi,Miao, Zehong,Zhang, Ao,Ding, Chunyong
, p. 17 - 28 (2015)
The sesquiterpene lactone framework of artemisinin was used as a drug repositioning prototype for the development of novel antitumor drugs. Several series of novel artemisinin analogues (artemalogues) were designed and synthesized through 1,3-dipolar cycloaddition of artemisitene with nitrile oxides or nitrones. The isoxazolidine-containing spirobicyclic artemalogue 11b turns out to be the most potent with low micromolar IC50 values against all three tumor cells, which were at least 4-to 14-fold more potent than the parent artemisinin.
Anti-proliferative and anti-malarial activities of spiroisoxazoline analogues of artemisinin
Pratap, Surya,Naaz, Fatima,Reddy, Srinivas,Jha, Kunal K.,Sharma, Kalicharan,Sahal, Dinakar,Akhter, Mymoona,Nayakanti, Devanna,Kumar, Halmuthur M. S.,Vandana,Pandey, Kailash,Shafi, Syed
, (2019)
A series of spiroisoxazoline analogues of artemisinin was synthesized by employing 1,3-dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All the synthesized compounds were tested for their anti-proliferative and anti
[...] and Isoxazolidine substituted artemisinin derivatives, preparation method and application thereof (by machine translation)
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Paragraph 0160, (2017/07/20)
The invention provides a [...] and Isoxazolidine substituted artemisinin derivatives, its preparation method and application, in particular, the invention provides a compound of formula I is shown. Wherein the definition of each group as described in the
