1011-47-8Relevant articles and documents
Synthesis of Aryl Methyl Ketones mediated by Cobalt Tetracarbonyl Anion
Miura, Masahiro,Akase, Fumiaki,Nomura, Masakatsu
, p. 241 - 242 (1986)
The reaction of aryl halides with excess of methyl iodide in the presence of cobalt tetracarbonyl anion (generated under phase-transfer conditions), gave aryl ketones along with aromatic carboxylic acids.
Chiral ferrocenyl ligands with bidentate pyridine donors. Synthesis and application in Pd-catalyzed asymmetric allylic alkylation of 1,3-diphenylpropenyl-1-esters
Mroczek, Agnieszka,Erre, Giulia,Taras, Rossana,Gladiali, Serafino
, p. 1921 - 1927 (2010)
A synthetic procedure relying on the Friedlaender condensation of enantiopure α-amino ferrocenecarboxaldeyde has been devised for the regio-designed elaboration of a pyridine nucleus fused onto the ferrocene scaffold. Three novel bidentate ligands with different pyridine nitrogen donors featuring the [3,2-b]ferrocenopyridine fragment a as the sole chirogenic element have been prepared in enantiopure form through a multi step route involving the diastereoselective deprotonation of a chiral acetal of ferrocenecarboxaldehyde in the stereodetermining step. The ligands were assessed in the Pd-catalyzed allylic alkylation of 1,3-diphenyl-2-propenyl esters with good stereoselectivity.
2-Quinolinecarboxaldehyde: an unusual partner in the Henry reaction and subsequent elimination
Nomland, Ashley,Hills, Ivory D.
, p. 5511 - 5514 (2008)
2-Quinolinecarboxaldehyde participates in a standard Henry reaction when combined with a nitroalkane and catalytic amounts of base. However, water is not readily eliminated from the resulting β-nitro alcohol intermediate to form the expected nitroalkene. Instead, the elimination of nitrous acid is observed furnishing an unexpected ketone product.
Simple and mild method for preparation of α-pyridinecarboxylates and α-pyridyl ketones via trimethylstannyl derivatives
Yamamoto,Ouchi,Tanaka
, p. 1028 - 1030 (1995)
Alkoxycarbonylation and acylation at the α-position of pyridine, quinoline, and isoquinoline via the respective trimethylstannyl derivatives were satisfactorily performed by employing ethyl chloroglyoxylate and acylformyl chloride under mild conditions.
Just Add the Gold: Aggregation-Induced-Emission Properties of Alkynylphosphinegold(I) Complexes Functionalized with Phenylene-Terpyridine Subunits
Abramova, Evgenia O.,Paderina, Aleksandra V.,Slavova, Sofia O.,Kostenko, Ekaterina A.,Eliseenkov, Eugene V.,Petrovskii, Stanislav K.,Gitlina, Anastasia Yu.,Boyarskiy, Vadim P.,Grachova, Elena V.
supporting information, p. 18715 - 18725 (2021/12/09)
A series of organometallic complexes containing an alkynylphosphinegold(I) fragment and a phenylene-terpyridine moiety connected together by flexible linker have been prepared using the specially designed terpyridine ligands. The compounds were studied cr
Metal-free C-H methylation and acetylation of heteroarenes with PEG-400
Kudale, Vishal Suresh,Wang, Jeh-Jeng
supporting information, p. 3506 - 3511 (2020/06/25)
The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O2and TsOH·H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.