101103-30-4

Basic information

• Product Name: N,N'-Bis-(4-chlor-benzyloxy)-harnstoff
• Synonyms: N,N'-Bis-(4-chlor-benzyloxy)-harnstoff
• CAS NO: 101103-30-4
• Molecular Weight: 341.194
• Mol File: 101103-30-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N,N'-Bis-(4-chlor-benzyloxy)-harnstoff(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-Bis-(4-chlor-benzyloxy)-harnstoff(101103-30-4)
• EPA Substance Registry System: N,N'-Bis-(4-chlor-benzyloxy)-harnstoff(101103-30-4)

Safety Data

• Hazardous Substances Data: 101103-30-4(Hazardous Substances Data)

Upstream product

• 5555-70-4 N-(4-Chlor-benzyloxy)-carbaminsaeure-ethylester 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 38936-60-6 O-(4-chlorobenzyl)hydroxylamine hydrochloride 
• 39030-46-1 2-((4-chlorobenzyl)oxy)isoindoline-1,3-dione 
• 530-62-1 1,1'-carbonyldiimidazole 
• 5555-51-1 (4-chlorobenzyl)oxyamine 
• 622-95-7 4-chlorobenzyl bromide 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 75-44-5 phosgene 

Relevant articles and documents

Vinylogous Aza-Michael Addition of Urea Derivatives with p-Quinone Methides Followed by Oxidative Dearomative Cyclization: Approach to Spiroimidazolidinone Derivatives

Herein, we report an efficient protocol for the synthesis of spiro-imidazolidinone-cyclohexadienones from p-quinone methides (p-QMs) and dialkyloxy ureas under mild conditions. The strategy follows a two-step process involving an initial vinylogous conjugate addition of urea derivatives to p-QMs, followed by oxidative dearomative cyclization of open-chain product to the projected spiro-imidazolidinones. This protocol exhibits good functional group tolerance and provides a straightforward method to access spiro-imidazolidinone-cyclohexadienones. In follow-up chemistry, we have shown the debenzylation of spiroimidazolidinones to give N-hydroxycyclic ureas. (Figure presented.).