1011525-96-4

Basic information

• Product Name: N'-(3-ethynylphenyl) N,N-dimethyl formamidine
• Synonyms: N'-(3-ethynylphenyl) N,N-dimethyl formamidine
• CAS NO: 1011525-96-4
• Molecular Weight: 172.23
• Mol File: 1011525-96-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N'-(3-ethynylphenyl) N,N-dimethyl formamidine(CAS DataBase Reference)
• NIST Chemistry Reference: N'-(3-ethynylphenyl) N,N-dimethyl formamidine(1011525-96-4)
• EPA Substance Registry System: N'-(3-ethynylphenyl) N,N-dimethyl formamidine(1011525-96-4)

Safety Data

• Hazardous Substances Data: 1011525-96-4(Hazardous Substances Data)

Upstream product

• 54060-30-9 3-acetylenephenylamine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 183321-74-6 erlotinib 

Relevant articles and documents

A PROCESS FOR SYNTHESIS OF [6,7-BIS-(2-METHOXYETHOXY)-QUINAZOLIN-4- YL]-(3-ETHYNYLPHENYL)AMINE HYDROCHLORIDE

A process for synthesizing [6,7-bis(2-methoxyethoxy)quinazolin-4-yl]-(3-ethynylphenyl)amine hydrochloride (Erlitinib Hydrochloride) having the formula (I) comprising reacting 3,4-dihydroxy benzaldehyde with bromo derivative of ethyl methyl ether to obtain 3,4-bis(2-methoxyethoxy)benzaldehyde having formula (III). This is converted to give 3,4- bis (2-methoxyethoxy)-benzonitrile. On further nitration we obtain 4,5- bis (2-methoxyethoxy)-2-nitrobenzonitrile which on nitro reduction we get 2-amino-4,5-bis(2-methoxyethoxy)benzonitrile and reacting this with N'-(3-ethynylphenyl)-N,N-dimethyl formamidine gives erlotinib free base. On further treatment of this free base with methanolic/ethanolic hydrochloric acid gives us erlotinib hydrochloride.