1012-18-6

Basic information

• Product Name: Benzene, 1-(2-methyl-1-propenyl)-4-nitro-
• CAS NO: 1012-18-6
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol File: 1012-18-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2-methyl-1-propenyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2-methyl-1-propenyl)-4-nitro-(1012-18-6)
• EPA Substance Registry System: Benzene, 1-(2-methyl-1-propenyl)-4-nitro-(1012-18-6)

Safety Data

• Hazardous Substances Data: 1012-18-6(Hazardous Substances Data)

Upstream product

• 122631-92-9 di(p-nitrobenzyl)-m-nitrophenylphosphine oxide 
• 555-16-8 4-nitrobenzaldehdye 
• 636-98-6 p-nitrobenzene iodide 
• 126689-00-7 2-methyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-propene 
• 24470-78-8 isopropyltriphenylphosphonium iodide 
• 100-44-7 benzyl chloride 
• 1754-74-1 2-chloro-2-methyl-1-phenylpropane 
• 100-14-1 4-nitrobenzyl chloride 
• 24163-39-1 sodium 2-nitropropane 
• 538-93-2 1-phenyl-2-methylpropane 
• 67-64-1 acetone 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 69278-42-8 p-(2-chloro-2-methylpropyl)nitrobenzene 
• 82571-90-2 (2-methoxycarbonyl-prop-2-yl) triphenylphosphonium iodide 

Downstream Products

• 69240-34-2 1,2-Dibromo-2-methyl-1-p-nitrophenylpropan 
• 69278-50-8 2-methoxy-2-methyl-1-(p-nitrophenyl)propane 
• 1036750-76-1 2-methyl-1-(4-nitrophenyl)propane-1,2-diol 
• 37542-81-7 (Z)-2-methyl-3-(4-nitrophenyl)prop-2-enol 
• 80998-15-8 N-Hydroxy-N-[4-(2-methyl-propenyl)-phenyl]-acetamide 
• 69278-42-8 p-(2-chloro-2-methylpropyl)nitrobenzene 
• 71724-44-2 p-(2-bromo-2-methylpropyl)nitrobenzene 
• 18755-60-7 2-methyl-3-p-nitrophenylprop-1-ene 
• 69240-35-3 α-Bromo-β,β-dimethyl-p-nitrostyrol 

Relevant articles and documents

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Electrochemical Vicinal Difluorination of Alkenes: Scalable and Amenable to Electron-Rich Substrates

Fluorinated alkyl groups are important motifs in bioactive compounds, positively influencing pharmacokinetics, potency and conformation. The oxidative difluorination of alkenes represents an important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their safety and scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochemical generation of a hypervalent iodine mediator using an “ex-cell” approach, which avoids oxidative substrate decomposition. The more sustainable conditions give good to excellent yields in up to decagram scales.

COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT

Compounds and compositions useful for treating disorders related to KIT and PDFGR are described herein.