101207-46-9

Basic information

• Product Name: 2-(3-methylbenzyl)isoindoline-1,3-dione
• Synonyms: 2-(3-methylbenzyl)isoindoline-1,3-dione
• CAS NO: 101207-46-9
• Molecular Weight: 251.285
• Mol File: 101207-46-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(3-methylbenzyl)isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-methylbenzyl)isoindoline-1,3-dione(101207-46-9)
• EPA Substance Registry System: 2-(3-methylbenzyl)isoindoline-1,3-dione(101207-46-9)

Safety Data

• Hazardous Substances Data: 101207-46-9(Hazardous Substances Data)

Upstream product

• 7223-50-9 N-propargylphthalimide 
• 78-79-5 isoprene 
• 85-44-9 phthalic anhydride 
• 100-81-2 3-methyl-benzenemethanamine 
• 620-13-3 1-bromomethyl-3-methyl-benzene 
• 1074-82-4 potassium phtalimide 

Downstream Products

• 100-81-2 3-methyl-benzenemethanamine 
• 88-99-3 benzene-1,2-dicarboxylic acid 

Relevant articles and documents

Alkoxide-Catalyzed Hydrosilylation of Cyclic Imides to Isoquinolines via Tandem Reduction and Rearrangement

An alkoxide-catalyzed hydrosilylation of cyclic imides to isoquinolines was realized via tandem reduction and rearrangement. Using TMSOK as the catalyst and (EtO)2MeSiH as the reductant, a series of cyclic imides containing different functional groups were reduced to the corresponding 3-aryl isoquinolines in moderate to good yields. The scenario of the reaction pathway was supposed to involve the reduction of imides to ω-hydroxylactams, which underwent rearrangement in the presence of a base catalyst, and then the carbonyl reduction, followed by siloxy elimination.

Benzylphthalimides and phenethylphthalimides with thalidomide-like activity on the production of tumor necrosis factor α

Benzylphthalimide analogs (P1P's) and phenethylphthalimide analogs (P2P's) have been found to exhibit thalidomide-like activity on the production of tumor necrosis factor (TNF)-α by the human leukemia cell line, HL-60, stimulated by 12-O-tetradecanoylphorbol-13-acetate (TPA). Structure-activity relationships are discussed on the basis of the TNF-α production-enhancing activity. Benzylphthalimide (P1P-00) exhibited activity which is weaker than that of thalidomide, but introduction of a methyl group at the ortho-position of the benzyl moiety (P1P-10) resulted an increase to a level comparable with that of thalidomide. Phenethylphthalimide (P2P-00) is more potent than thalidomide, and its fluorinated derivative, 2-phenethyl-4,5,6,7-tetrafluoro- 1H-isoindole-1,3-dione (FP2P-00), exhibited potent activity at very low concentrations.