101253-89-8

Basic information

• Product Name: [1-(2-methoxy-phenyl)-ethyl]-malonic acid diethyl ester
• Synonyms: [1-(2-methoxy-phenyl)-ethyl]-malonic acid diethyl ester
• CAS NO: 101253-89-8
• Molecular Weight: 294.348
• Mol File: 101253-89-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [1-(2-methoxy-phenyl)-ethyl]-malonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(2-methoxy-phenyl)-ethyl]-malonic acid diethyl ester(101253-89-8)
• EPA Substance Registry System: [1-(2-methoxy-phenyl)-ethyl]-malonic acid diethyl ester(101253-89-8)

Safety Data

• Hazardous Substances Data: 101253-89-8(Hazardous Substances Data)

Upstream product

• 1462-12-0 diethyl ethylidenemalonate 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 105-53-3 diethyl malonate 
• 135-02-4 ortho-anisaldehyde 
• 917-64-6 methyl magnesium iodide 
• 6768-22-5 diethyl 2-methoxybenzylidenemalonate 

Relevant articles and documents

General access to C-centered radicals: Combining a bioinspired photocatalyst with boronic acids in aqueous media

Carbon-centered radicals are indispensable building blocks for modern synthetic chemistry. In recent years, visible light photoredox catalysis has become a promising avenue to access C-centered radicals from a broad array of latent functional groups, including boronic acids. Herein, we present an aqueous protocol wherein water features a starring role to help transform aliphatic, aromatic, and heteroaromatic boronic acids to C-centered radicals with a bioinspired flavin photocatalyst. These radicals are used to deliver a diverse pool of alkylated products, including three pharmaceutically relevant compounds, via open-shell conjugate addition to disparate Michael acceptors. The mechanism of the reaction is investigated by computational studies, deuterium labeling, radical-trapping experiments, and spectroscopic analysis.