1013068-79-5

Basic information

• Product Name: C₁₂H₁₅NO₃
• CAS NO: 1013068-79-5
• Molecular Weight: 221.256
• Mol File: 1013068-79-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₅NO₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₅NO₃(1013068-79-5)
• EPA Substance Registry System: C₁₂H₁₅NO₃(1013068-79-5)

Safety Data

• Hazardous Substances Data: 1013068-79-5(Hazardous Substances Data)

Upstream product

• 22802-67-1 methyl 2-methoxy-5-aminobenzoate 
• 135-95-5 3-hydroxymethyl-4-methoxyaniline 
• 34841-11-7 methyl 2-methoxy-5-nitrobenzoate 

Downstream Products

• 943513-53-9 C₃₃H₃₄FN₃O₅ 

Relevant articles and documents

Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: Benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety

Following the discovery of JTK-109 (1) as a potent inhibitor of hepatitis C virus NS5B RNA-dependent RNA polymerase, [(a) Hirashima, S.; Suzuki, T.; Ishida, T.; Noji, S.; Yata, S.; Ando, I.; Komatsu, M.; Ikeda, S.; Hashimoto, H. J. Med. Chem. 2006, 49, 4721. (b) Hashimoto, H.; Mizutani, K.; Yoshida, A. Int. Patent Appl. WO 01/47883, 2001.] further studies toward the improvement of the cellular potency have been performed. A greater than 40-fold improvement was achieved through replacing the biphenyl moiety with a 2-morpholinophenyl group and the benzimidazole ring with the tetracyclic scaffold to afford compound 7 with an excellent replicon potency (EC50 = 7.6 nM).