101330-11-4

Basic information

• Product Name: (2-Iodoquinolin-3-yl)-methanol
• Synonyms: (2-Iodoquinolin-3-yl)-methanol;(2-iodo-3-quinolinyl)methanol
• CAS NO: 101330-11-4
• Molecular Formula: C₁₀H₈INO
• Molecular Weight: 285.09
• Mol File: 101330-11-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-Iodoquinolin-3-yl)-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Iodoquinolin-3-yl)-methanol(101330-11-4)
• EPA Substance Registry System: (2-Iodoquinolin-3-yl)-methanol(101330-11-4)

Safety Data

• Hazardous Substances Data: 101330-11-4(Hazardous Substances Data)

Usage

Description

(2-Iodoquinolin-3-yl)-methanol is a chemical compound that features a quinoline ring with an iodine atom and a hydroxyl group attached. It is a white to off-white crystalline powder known for its role as an intermediate in the synthesis of pharmaceuticals and organic compounds.

Uses

Used in Pharmaceutical Industry:
(2-Iodoquinolin-3-yl)-methanol is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and enhancing the properties of existing ones.
Used in Organic Chemistry:
In the field of organic chemistry, (2-Iodoquinolin-3-yl)-methanol serves as a building block for other chemical reactions, facilitating the creation of diverse organic compounds for research and practical applications.
It is crucial to handle and store (2-Iodoquinolin-3-yl)-methanol with care due to its potential health and environmental hazards, making it a valuable yet cautiously managed tool in chemical research and development.

Upstream product

• 125917-60-4 2-chloro-3-(hydroxymethyl)quinoline 
• 80231-40-9 2-iodo-3-quinolinecarboxaldehyde 
• 73568-25-9 2-chloro-3-quinoline carboxaldehyde 
• 103-84-4 Acetanilid 

Downstream Products

• 13669-51-7 3-Hydroxymethylquinoline 
• 101330-12-5 2-deuterio-3-(hydroxymethyl)quinoline 
• 127183-66-8 2-iodo-3-(hydroxymethyl)quinoline benzoate ester 
• 929803-51-0 N-[(2-iodoquinolin-3-yl)methyl]benzamide 
• 929803-52-1 N-cyano-N-[(2-iodoquinolin-3-yl)methyl]benzamide 
• 127183-70-4 2-benzoyl-3-(hydroxymethyl)quinoline 
• 1198104-75-4 C₁₇H₁₄INO₂S 
• 1198104-83-4 C₁₇H₁₁F₃INO₂S 
• 1198104-76-5 C₁₈H₁₄INO₄S 

Relevant articles and documents

Vinyl isocyanates in alkaloid synthesis. Camptothecin model studies

Model studies directed toward camptothecin employing a vinyl isocyanateenamine cyclocondensation as the key synthetic step are reported.

Intermediates and method of making camptothecin and camptothecin analogs

Compounds of Formula I STR1 are made in accordance with the following scheme: STR2 wherein R may be loweralkyl; R1 may be H, loweralkyl, loweralkoxy, or halo; R2, R3, R4, and R5 may each independently be H, amino, hydroxy, loweralkyl, loweralkoxy, loweralkylthio, di(loweralkyl)amino, cyano, methylenedioxy, formyl, nitro, halo, trifluoromethyl, aminomethyl, azido, amido, hydrazino, or any of the twenty standard amino acids bonded to the A ring via the amino-nitrogen atom; Y is H and W and X are halogen. Also disclosed are novel processes for making starting materials for the scheme given above, and novel intermediates employed in these processes.

Evidence in favor of lithium-halogen exchange being faster than lithium-acidic hydrogen (deuterium) exchange

Treatment of 2-iodo-3-(deuterioxymethyl)quinoline with 1.5 equiv of n-butyllithium in ether, followed by aqueous work up, furnished 2-deuterio-3-(hydroxymethyl)quinoline in greater than 50% yield, confirming our earlier report,2 which has been