101337-87-5

Basic information

• Product Name: N-desmethylrufloxacin
• Synonyms: N-desmethylrufloxacin
• CAS NO: 101337-87-5
• Molecular Formula: C16H16FN3O3S
• Molecular Weight: 349.3799432
• Mol File: 101337-87-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 605.1°C at 760 mmHg
• Flash Point: 319.8°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 1.7E-15mmHg at 25°C
• Refractive Index: 1.731
• CAS DataBase Reference: N-desmethylrufloxacin(CAS DataBase Reference)
• NIST Chemistry Reference: N-desmethylrufloxacin(101337-87-5)
• EPA Substance Registry System: N-desmethylrufloxacin(101337-87-5)

Safety Data

• Hazardous Substances Data: 101337-87-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16FN3O3S/c17-11-7-9-12-15(13(11)19-3-1-18-2-4-19)24-6-5-20(12)8-10(14(9)21)16(22)23/h7-8,18H,1-6H2,(H,22,23)

Upstream product

• 101337-86-4 8-Fluoro-1,6-dioxo-9-piperazin-1-yl-2,3-dihydro-1H,6H-1λ⁴-thia-3a-aza-phenalene-5-carboxylic acid 
• 101363-10-4 rufloxacin 
• 367-21-5 3-chloro-4-fluorophenylamine 
• 101337-96-6 8-chloro-7-fluoro-3,4-dihydro-2H-1,4-benzothiazine 
• 101337-95-5 8-chloro-7-fluoro-3-oxo-3,4-dihydro-2H-1,4-benzothiazine 
• 101337-81-9 10-chloro-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylic acid 
• 101337-84-2 10-chloro-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylic acid 1-oxide 
• 101337-97-7 ethyl 10-chloro-9-fluoro-7-oxo-2,3-dihydro-7H-pyrido<1,2,3-de><1,4>benzothiazine-6-carboxylate 

Relevant articles and documents

Photoinduced N-demethylation of rufloxacin and its methyl ester under aerobic conditions

Irradiation of rufloxacin (RF) under aerobic conditions gives rise to N-demethylation of the piperazinyl ring, which is enhanced in aerated D2O. Two primary processes seem to be involved in RF N-demethylation: photoionization from 1RF and singlet oxygen generation from 3RF. Both processes may lead to the same key intermediates, namely, RF-+ and superoxide radical anion; coupling of these intermediates explains N-demethylation of RF via an iminium cation. Formation of the hydrated electron by a monophotonic process (with a quantum yield of 0.09) is detected along with 3RF (with a intersystem-crossing quantum yield πISC = 0.36) by laser flash photolysis. Studies performed on RF methyl ester give qualitatively similar results.

Quinolonecarboxylic Acids. 2. Synthesis and Antibacterial Evaluation of 7-Oxo-2,3-dihydro-7H-pyridobenzothiazine-6-carboxylic Acids

A series of pyridobenzothiazine acid derivatives was synthesized and their in vitro antibacterial activity was evaluated.The 1,4-benzothiazine intermediates, which by Gould-Jacobs quinoline synthesis produced pyridobenzothiazine acids, were prepared by hydrolytic basic cleavage of substituted 2-aminobenzothiazoles and successive cyclocondensation with 1-bromo-2-chloroethane or alternatively with monochloroacetic acid, hence reduction by LiAlH4.The pyridobenzothiazine acids 10c, 30, and 31 show potent antibacterial activities against Gram-positive and Gram-negative pathogens.Structure-activity relationships are discussed.The compound 9-fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyridobenzothiazine-6-carboxylic acid (31) (MF-934) has been found to possess, together with the antibacterial activity, a weak acute toxicity and interesting pharmacokinetic characteristics in several animal species (rat, dog, monkey, man).