1013643-01-0Relevant articles and documents
Design of two new chemotypes for inhibiting the Janus kinase 2 by scaffold morphing
Furet, Pascal,Gerspacher, Marc,Pissot-Soldermann, Carole
supporting information; scheme or table, p. 1858 - 1860 (2010/07/04)
JAK2 is a target of high interest in chronic myeloproliferative disorders drug research. Starting from a screening hit, two new JAK2 inhibitor chemotypes were designed by scaffold morphing. The prototype compounds of these new series showed nanomolar inhi