1013918-98-3Relevant articles and documents
Synthesis and anti-HIV activity of GS-9148 (2′-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor
Boojamra, Constantine G.,Mackman, Richard L.,Markevitch, David Y.,Prasad, Vidya,Ray, Adrian S.,Douglas, Janet,Grant, Deborah,Kim, Choung U.,Cihlar, Tomas
, p. 1120 - 1123 (2008/09/18)
GS-9148 (2′-Fd4AP, 4) has been identified as a nucleoside phosphonate reverse transcriptase (RT) inhibitor with activity against wild-type HIV (EC50 = 12 μM). Unlike many clinical RT inhibitors, relevant reverse transcriptase mutants (M184V, K6