1013921-36-2 Usage
Description
H2N-PEG4-Propyne, also known as Propargyl-PEG4-amine, is a versatile chemical compound featuring a propargyl group and an amine group. The amine group is reactive with carboxylic acids, activated NHS esters, and carbonyls, while the propargyl group can form a triazole linkage with azide-bearing biomolecules. The hydrophilic PEG4 (polyethylene glycol) spacer enhances the water solubility of this reagent, facilitating the easy modification of carboxylic acid-containing biomolecules such as antibodies, proteins, and peptides with the terminal alkyne. Additionally, the PEG spacer reduces aggregation of modified proteins stored in solution by adding hydrophilic character.
Uses
Used in Bioconjugation:
H2N-PEG4-Propyne is used as a bioconjugation agent for the modification of biomolecules, such as antibodies, proteins, and peptides. The expression is: H2N-PEG4-Propyne is used as a bioconjugation agent for the modification of biomolecules to enhance their solubility and reduce aggregation.
Used in Pharmaceutical Industry:
H2N-PEG4-Propyne is used as a drug delivery enhancer for improving the bioavailability and therapeutic outcomes of various drugs. The expression is: H2N-PEG4-Propyne is used as a drug delivery enhancer for improving the bioavailability and therapeutic outcomes of drugs by facilitating their conjugation with biomolecules.
Used in Diagnostics:
H2N-PEG4-Propyne is used as a diagnostic tool for the detection and imaging of various biological processes due to its ability to form stable conjugates with target biomolecules. The expression is: H2N-PEG4-Propyne is used as a diagnostic tool for the detection and imaging of biological processes through stable biomolecule conjugation.
Used in Research and Development:
H2N-PEG4-Propyne is used as a research tool for the development of new bioconjugates and the study of biomolecular interactions. The expression is: H2N-PEG4-Propyne is used as a research tool for the development of new bioconjugates and the study of biomolecular interactions, providing insights into various biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 1013921-36-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,1,3,9,2 and 1 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1013921-36:
(9*1)+(8*0)+(7*1)+(6*3)+(5*9)+(4*2)+(3*1)+(2*3)+(1*6)=102
102 % 10 = 2
So 1013921-36-2 is a valid CAS Registry Number.
1013921-36-2Relevant articles and documents
Functional virus-based polymer-protein nanoparticles by atom transfer radical polymerization
Pokorski, Jonathan K.,Breitenkamp, Kurt,Liepold, Lars O.,Qazi, Shefah,Finn
, p. 9242 - 9245 (2011)
Viruses and virus-like particles (VLPs) are useful tools in biomedical research. Their defined structural attributes make them attractive platforms for engineered interactions over large molecular surface areas. In this report, we describe the use of VLPs as multivalent macroinitiators for atom transfer radical polymerization. The introduction of chemically reactive monomers during polymerization provides a robust platform for post-synthetic modification via the copper-catalyzed azide-alkyne cycloaddition reaction. These results provide the basis to construct nanoparticle delivery vehicles and imaging agents using protein-polymer conjugates.
Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues
Hwang, Dobeen,Nilchan, Napon,Nanna, Alex R.,Li, Xiaohai,Cameron, Michael D.,Roush, William R.,Park, HaJeung,Rader, Christoph
, p. 1229 - 9,1239 (2019)
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COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION
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, (2021/06/11)
The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.
A MedChem toolbox for cereblon-directed PROTACs
Steinebach, Christian,Sosi?, Izidor,Lindner, Stefanie,Bricelj, Ale?a,Kohl, Franziska,Ng, Yuen Lam Dora,Monschke, Marius,Wagner, Karl G.,Kr?nke, Jan,Gütschow, Michael
, p. 1037 - 1041 (2019/06/27)
A modular chemistry toolbox was developed for cereblon-directed PROTACs. A variety of linkers was attached to a CRBN ligand via the 4-amino position of pomalidomide. We used linkers of different constitution to modulate physicochemical properties. We equipped one terminus of the linker with a set of functional groups, e.g. protected amines, protected carboxylic acids, alkynes, chloroalkanes, and protected alcohols, all of which are considered to be attractive for PROTAC design. We also highlight different opportunities for the expansion of the medicinal chemists' PROTAC toolbox towards heterobifunctional molecules, e.g. with biotin, fluorescent, hydrophobic and peptide tags.
