1013930-64-7Relevant articles and documents
Structure-based optimization of pyrazolo[3,4-d]pyrimidines as Abl inhibitors and antiproliferative agents toward human leukemia cell lines
Manetti, Fabrizio,Brullo, Chiara,Magnani, Matteo,Mosci, Francesca,Chelli, Beatrice,Crespan, Emmanuele,Schenone, Silvia,Naldini, Antonella,Bruno, Olga,Trincavelli, Maria Letizia,Maga, Giovanni,Carraro, Fabio,Martini, Claudia,Bondavalli, Francesco,Botta, Maurizio
, p. 1252 - 1259 (2008/09/20)
Results from molecular docking calculations and Grid mapping laid the foundations for a structure-based optimization approach to improve the biological properties of pyrazolo-pyrimidine derivatives in terms of inhibition of Abl enzymatic activity and anti