1013932-70-1Relevant articles and documents
On water phosphine-free palladium-catalyzed room temperature C-H arylation of indoles
Islam, Saidul,Larrosa, Igor
, p. 15093 - 15096 (2013)
Get on top of your chemistry! An "on water", palladium-catalyzed, phosphine-free direct C-H arylation of indoles, with iodoarenes at 25-30°C, is disclosed (see scheme; TBDMS=N-tert-butyldimethylsilyl ether; SEM=N-2-(trimethylsilyl)ethoxymethyl; Bn=benzyl, Piv=pivabyl). The mildness of the reaction conditions permits the tolerance of a variety of N1-protected indoles.