101467-70-3Relevant articles and documents
A concise synthesis of polyhydroxydihydrochalcones and homoisoflavonoids
Siddaiah, Vidavalur,Rao, Chunduri Venkata,Venkateswarlu, Somepalli,Subbaraju, Gottumukkala V.
, p. 841 - 846 (2007/10/03)
A general and single step synthesis of polyhydroxydihydrochalcones from the readily available phenols and dihydrocinnamic acids using BF 3·Et2O is described. The method allows the synthesis of a wide range of compounds with multiple phenolic hydroxyls and other substituents. These dihydrochalcones are converted into homoisoflavonoids by DMF/PCl5 and the methodology has been applied to the synthesis of naturally occurring phloretin and 5,7-dihydroxy-3-[(4-hydroxyphenyl)methyl]-4H- chromen-4-one. The antioxidant activity of dihydrochalcones and homoisoflavonoids was determined by superoxide free radical (NBT) and DPPH free radical scavenging methods. Polyhydroxydihydrochalcones 3c, 3f, 3g and homoisoflavonoids 4c, 4f, 4g displayed excellent antioxidant activity.
Chemistry of Homoisoflavonoids: Synthesis of Polyhydroxy 3-Benzylchromones and 3-Benzylchroman-4-ones without Protection and Deprotection of Hydroxyl Groups and a Convenient Preparation of Benzylidenechroman-4-ones
Sathyanarayana, S.,Krishnamurty, H. G.
, p. 899 - 901 (2007/10/02)
Catalytic transfer hydrogenation of hydroxyflavanones gives hydroxydihydrochalcones.These dihydrochalcones are converted into hydroxyhomoisoflavones and homoisoflavanones without protection and deprotection of hydroxyl groups.The condensation between chromanones and aryl aldehydes in the presence of dry p-toluenesulfonic acid in benzene or toluene gives benzylidenechromanones in good yields.The method is far superior to all other existing procedures.
