10147-45-2 Usage
Description
(3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate is a pale yellow solid with unique chemical properties. It is a steroidal compound derived from corticosterone, featuring a 21-acetate functional group and a tetracyclic ring structure. (3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate is characterized by its specific stereochemistry at the 3β and 5β positions, which influences its biological activity and potential applications.
Uses
Used in Pharmaceutical Industry:
(3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate is used as a pharmaceutical agent for its efficient blocking activity towards 3α-hydroxypregnane-steroid action. This property makes it a candidate for the development of drugs targeting steroid hormone-related conditions, such as adrenal disorders or certain cancers that are influenced by steroid hormones.
Used in Research Applications:
In the field of scientific research, (3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate serves as an important tool for studying the mechanisms of steroid hormone action and the development of novel therapies. Its minimal activity against GABA (gamma-aminobutyric acid) suggests that it may have selective effects on steroid hormone receptors, which could be useful in understanding the specific pathways involved in steroid hormone signaling.
Used in Chemical Synthesis:
As a steroidal compound with a unique structure, (3β,5β)-Tetrahydro 11-Deoxycorticosterone 21-Acetate can be used as a starting material or intermediate in the synthesis of other steroidal drugs or compounds with potential therapeutic applications. Its chemical properties, such as its pale yellow solid form, may also be advantageous in certain synthetic processes or purification techniques.
Check Digit Verification of cas no
The CAS Registry Mumber 10147-45-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,4 and 7 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 10147-45:
(7*1)+(6*0)+(5*1)+(4*4)+(3*7)+(2*4)+(1*5)=62
62 % 10 = 2
So 10147-45-2 is a valid CAS Registry Number.
10147-45-2Relevant articles and documents
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Reichstein,v.Euw
, p. 1209,1211 (1939)
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Novel steroid inhibitors of glucose 6-phosphate dehydrogenase
Hamilton, Niall M.,Dawson, Martin,Fairweather, Emma E.,Hamilton, Nicola S.,Hitchin, James R.,James, Dominic I.,Jones, Stuart D.,Jordan, Allan M.,Lyons, Amanda J.,Small, Helen F.,Thomson, Graeme J.,Waddell, Ian D.,Ogilvie, Donald J.
supporting information; experimental part, p. 4431 - 4445 (2012/09/11)
Novel derivatives of the steroid DHEA 1, a known uncompetitive inhibitor of G6PD, were designed, synthesized, and tested for their ability to inhibit this dehydrogenase enzyme. Several compounds with approximately 10-fold improved potency in an enzyme assay were identified, and this improved activity translated to efficacy in a cellular assay. The SAR for steroid inhibition of G6PD has been substantially developed; the 3β-alcohol can be replaced with 3β-H-bond donors such as sulfamide, sulfonamide, urea, and carbamate. Improved potency was achieved by replacing the androstane nucleus with a pregnane nucleus, provided a ketone at C-20 is present. For pregnan-20-ones incorporation of a 21-hydroxyl group is often beneficial. The novel compounds generally have good physicochemical properties and satisfactory in vitro DMPK parameters. These derivatives may be useful for examining the role of G6PD inhibition in cells and will assist the future design of more potent steroid inhibitors with potential therapeutic utility.
